INT154683

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syt17) molecular_function (Syt17) biological_process (Syt17)
Anatomy Link Frequency
neurons 1
Syt17 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 27 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
nociceptor 6 99.96 Very High Very High Very High
Adelta 1 99.70 Very High Very High Very High
Pain 3 98.36 Very High Very High Very High
Hyperalgesia 2 98.00 Very High Very High Very High
agonist 2 81.24 Quite High
antagonist 1 80.28 Quite High
b2 receptor 1 79.84 Quite High
Peripheral sensitization 1 78.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 100.00 Very High Very High Very High
Hypersensitivity 5 98.52 Very High Very High Very High
Pain 2 98.36 Very High Very High Very High
Hyperalgesia 2 98.00 Very High Very High Very High
Nociception 4 75.00 Quite High
Targeted Disruption 1 50.88 Quite High
Ganglion Cysts 3 28.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin (BK), a major inflammatory mediator, excites and sensitizes nociceptor neurons/fibers, thus evoking pain and hyperalgesia.
BK Binding (sensitizes) of in neurons associated with pain, hyperalgesia, inflammation, nociceptor and bradykinin
1) Confidence 0.19 Published 2008 Journal Neurosci. Res. Section Abstract Doc Link 18789982 Disease Relevance 0.44 Pain Relevance 0.72
In contrast, esophageal vagal afferent Adelta fibers do not respond to BK or AITC and fail to show mechanical hypersensitivity after BK perfusion.
BK Neg (fail) Binding (respond) of associated with adelta, hypersensitivity and bradykinin
2) Confidence 0.03 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19033534 Disease Relevance 0.43 Pain Relevance 0.71

General Comments

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