INT15509

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 14
Total Number 19
Disease Relevance 13.13
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HMBS) small molecule metabolic process (HMBS) nucleus (HMBS)
cytoplasm (HMBS)
Anatomy Link Frequency
erythrocyte 2
Urine 1
HMBS (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 99.80 Very High Very High Very High
anesthesia 11 99.44 Very High Very High Very High
abdominal pain 13 96.96 Very High Very High Very High
alcohol 3 96.08 Very High Very High Very High
Pain 5 91.76 High High
tetrodotoxin 10 90.20 High High
Analgesic 1 86.04 High High
Inflammation 3 56.60 Quite High
depression 4 31.36 Quite Low
Glutamate receptor 16 25.12 Quite Low
Disease Link Frequency Relevance Heat
Porphyria 71 100.00 Very High Very High Very High
Metabolic Disorder 1 99.78 Very High Very High Very High
Hepatic Porphyrias 4 99.72 Very High Very High Very High
INFLAMMATION 3 99.68 Very High Very High Very High
Congenital Anomalies 1 99.28 Very High Very High Very High
Cancer 7 99.24 Very High Very High Very High
Acute Intermittent Porphyria 12 99.18 Very High Very High Very High
Infection 7 97.48 Very High Very High Very High
Abdominal Pain 13 96.96 Very High Very High Very High
Disease 21 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diagnosis of AIP was established by the demonstration of reduced erythrocyte porphobilinogen deaminase (PBGD) activity and a point mutation (CAG --> CGG) in a splicing site in intron 10/exon 11 in the PBGD gene by DNA analysis.
Negative_regulation (reduced) of PBGD in erythrocyte associated with acute intermittent porphyria
1) Confidence 0.58 Published 2004 Journal Rinsho Ketsueki Section Abstract Doc Link 15359917 Disease Relevance 0.97 Pain Relevance 0.27
Since porphobilinogen deaminase activity was clearly decreased, diagnosis of acute intermittent porphyria could be confirmed.
Negative_regulation (decreased) of porphobilinogen deaminase associated with porphyria
2) Confidence 0.57 Published 2010 Journal Med. Klin. (Munich) Section Abstract Doc Link 20455047 Disease Relevance 1.29 Pain Relevance 0.24
The basic biochemical defect is reduced activity of the enzyme porphobilinogen deaminase.
Negative_regulation (reduced) of porphobilinogen deaminase
3) Confidence 0.50 Published 1998 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 9823563 Disease Relevance 1.05 Pain Relevance 0.14
Acute intermittent porphyria (AIP), an autosomal dominant disorder, is caused by partial deficiency of hydroxymethylbilane synthase (HMBS) affecting heme biosynthesis.
Spec (partial) Negative_regulation (deficiency) of hydroxymethylbilane synthase associated with porphyria
4) Confidence 0.46 Published 2008 Journal Ann. Hum. Genet. Section Abstract Doc Link 18627369 Disease Relevance 0.82 Pain Relevance 0.09
Moreover, these reporters can aid the identification and development of novel anti-cancer and anti-inflammatory drugs based on UPS inhibition.
Negative_regulation (inhibition) of UPS associated with inflammation, cancer and cinod
5) Confidence 0.37 Published 2005 Journal Essays Biochem. Section Abstract Doc Link 16250901 Disease Relevance 0.42 Pain Relevance 0.13
Acute intermittent porphyria is an autosomal dominantly inherited disorder, classified as acute hepatic porphyria, caused by a deficiency of hydroxymethylbilane synthase (EC 2.5.1.61, EC 4.3.1.8, also known as porphobilinogen deaminase, uroporphyrinogen I synthase), the third enzyme in heme biosynthesis.
Negative_regulation (deficiency) of hydroxymethylbilane synthase associated with porphyria and hepatic porphyrias
6) Confidence 0.35 Published 2009 Journal FEBS J. Section Abstract Doc Link 19292878 Disease Relevance 0.58 Pain Relevance 0.08
The increase of Urine ALA at 268 micromol/l (N<38) and of at 235 micromol/l (N<5) strongly suggested AIP that was further confirmed by PBG desaminase deficiency in red cells.
Negative_regulation (deficiency) of PBG desaminase in Urine associated with porphyria
7) Confidence 0.33 Published 2007 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 18033050 Disease Relevance 1.58 Pain Relevance 0.27
Acute Intermittent Porphyria (AIP) is an autosomal dominant inherited disorder because of a partial defect in Porphobilinogen Deaminase (PBGD), the third enzyme in the heme biosynthetic pathway.
Spec (partial) Negative_regulation (defect) of Porphobilinogen associated with porphyria
8) Confidence 0.30 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.48 Pain Relevance 0.07
Acute Intermittent Porphyria (AIP) is an autosomal dominant inherited disorder because of a partial defect in Porphobilinogen Deaminase (PBGD), the third enzyme in the heme biosynthetic pathway.
Spec (partial) Negative_regulation (defect) of PBGD associated with porphyria
9) Confidence 0.30 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.48 Pain Relevance 0.07
These mice exhibit the typical biochemical characteristics of human AIP, notably, decreased hepatic Pbgd activity, increased delta-aminolevulinic acid synthase activity and massively increased urinary excretion of the heme precursor, delta-aminolevulinic acid after treatment with drugs such as phenobarbital.
Negative_regulation (decreased) of Pbgd associated with porphyria
10) Confidence 0.23 Published 1996 Journal Nat. Genet. Section Abstract Doc Link 8563760 Disease Relevance 1.05 Pain Relevance 0.13
AIP is an autosomal dominant condition with incomplete penetrance, caused by deficiency of porphobilinogen deaminase, an enzyme found in the synthetic pathway for heme.
Negative_regulation (deficiency) of porphobilinogen deaminase associated with porphyria
11) Confidence 0.14 Published 2005 Journal Paediatr Anaesth Section Abstract Doc Link 15828996 Disease Relevance 0.62 Pain Relevance 0.32
Acute intermittent porphyria (AIP) is an inherited metabolic disorder caused by deficiency of porphobilinogen deaminase, an enzyme found in the synthetic pathway of heme.
Negative_regulation (deficiency) of porphobilinogen deaminase associated with metabolic disorder and porphyria
12) Confidence 0.14 Published 2006 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17037005 Disease Relevance 0.88 Pain Relevance 0.17
Anesthesia in a child with homozygous porphobilinogen deaminase deficiency: a severe form of acute intermittent porphyria.
Negative_regulation (deficiency) of porphobilinogen deaminase associated with anesthesia and porphyria
13) Confidence 0.10 Published 2005 Journal Paediatr Anaesth Section Title Doc Link 15828996 Disease Relevance 0.62 Pain Relevance 0.34
Acute intermittent porphyria is an autosomal dominant disorder defined by a partial deficiency of porphobilinogen deaminase (EC 4.3.1.8).
Spec (partial) Negative_regulation (deficiency) of porphobilinogen deaminase associated with porphyria
14) Confidence 0.08 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1733614 Disease Relevance 0.34 Pain Relevance 0.09
Biochemical abnormalities are thought to result from primary defects of porphobilinogen deaminase (PBGD; also called hydroxymethyl bilane synthase), the third enzyme of the heme synthesis pathway, and consecutive hepatic overexpression of the first enzyme of the pathway, 5-aminolevulinate synthase.
Negative_regulation (defects) of porphobilinogen deaminase associated with congenital anomalies
15) Confidence 0.06 Published 1998 Journal Semin. Liver Dis. Section Abstract Doc Link 9516674 Disease Relevance 0.68 Pain Relevance 0.14
There is ample literature evidence that inhibition of the UPS pathway, e.g. by the use of peptide aldehyde inhibitors including MG132, promotes the rapid activation of HSF1 [19], [20], [21].
Negative_regulation (inhibition) of UPS
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.09 Pain Relevance 0
The diagnosis of acute intermittent porphyria was confirmed by a high urinary excretion of porphobilinogen and a low level of erythrocyte hydroxymethylbilane synthase activity.
Negative_regulation (level) of erythrocyte hydroxymethylbilane synthase in erythrocyte associated with porphyria
17) Confidence 0.03 Published 1989 Journal Taiwan Yi Xue Hui Za Zhi Section Abstract Doc Link 2809566 Disease Relevance 0.87 Pain Relevance 0.16
Frequently, these aggregates contain ubiquitylated proteins and proteasomes, and it has often been suggested that impairment of the UPS underlies neurodegeneration (Sherman and Goldberg, 2001; Rubinsztein, 2006; Bedford et al., 2008b).
Negative_regulation (impairment) of UPS
18) Confidence 0.02 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.28 Pain Relevance 0
We next investigated the mechanisms responsible for the long-lasting reduction in UPS activity.
Negative_regulation (reduction) of UPS
19) Confidence 0.02 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0.09

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