INT1552

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 106
Total Number 107
Disease Relevance 8.15
Pain Relevance 37.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
neurons 16
spike 2
ACC 2
nerves 2
synapse 2
EPSPS (Populus trichocarpa)
Pain Term Frequency Confidence Heat
depression 972 100.00 Very High Very High Very High
isoflurane 155 99.98 Very High Very High Very High
fluoxetine 2 99.98 Very High Very High Very High
Dopamine 1960 99.98 Very High Very High Very High
opiate 23 99.92 Very High Very High Very High
Glutamate receptor 77 99.90 Very High Very High Very High
opioid receptor 13 99.88 Very High Very High Very High
Morphine 6 99.84 Very High Very High Very High
tetrodotoxin 107 99.84 Very High Very High Very High
nMDA receptor 591 99.80 Very High Very High Very High
Disease Term Frequency Confidence Heat
Depression 974 100.00 Very High Very High Very High
Ganglion Cysts 38 99.82 Very High Very High Very High
Convulsion 15 99.08 Very High Very High Very High
Nociception 71 97.88 Very High Very High Very High
Epilepsy 4 97.40 Very High Very High Very High
Subacute Sclerosing Panencephalitis 1 93.40 High High
Disease 147 93.12 High High
Neuropathic Pain 8 91.20 High High
Targeted Disruption 8 89.60 High High
Pain 68 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EPSPs were reversibly inhibited by approximately 50% during application of 30 microM NE.
Negative_regulation (inhibited) of EPSPs
1) Confidence 0.58 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1328562 Disease Relevance 0 Pain Relevance 0.27
RESULTS: Neuropathic pain caused significant suppression of EPSPs in the ACC compared with rats subjected to sham surgery.
Negative_regulation (suppression) of EPSPs in ACC
2) Confidence 0.52 Published 2008 Journal Brain Res. Section Body Doc Link 18786516 Disease Relevance 0.09 Pain Relevance 0
'Fast' EPSPs were abolished by all types of pontine lesions interrupting transmission through the contralateral 'abducens region' and may thus be relayed by internuclear neurons within or adjacent to the 6th nucleus.
Negative_regulation (abolished) of EPSPs in neurons
3) Confidence 0.50 Published 1979 Journal Exp Brain Res Section Abstract Doc Link 385333 Disease Relevance 0 Pain Relevance 0.11
Blockade of somatic sodium channels by local somatic ejection of tetrodotoxin (TTX), or inclusion of QX314 (an intracellular sodium channel blocker) in the recording pipette, reduced the evoked EPSPs and completely eliminated their voltage dependence.
Negative_regulation (reduced) of EPSPs associated with addiction, tetrodotoxin and sodium channel
4) Confidence 0.48 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11600624 Disease Relevance 0 Pain Relevance 0.73
Consistent with a focal action upon glutamatergic nerve terminals, the 5-HT-induced EPSPs can be suppressed by presynaptic inhibitory modulators such as mu-opiate or group II/III metabotropic agonists.
Negative_regulation (suppressed) of EPSPs in nerve associated with agonist and opiate
5) Confidence 0.42 Published 1998 Journal Biol. Psychiatry Section Abstract Doc Link 9836015 Disease Relevance 0.13 Pain Relevance 0.86
Riluzole produced a 36 +/- 17% depression of fiver volley amplitudes, which, based on input/output analysis, could completely account for the depression of EPSPs.
Negative_regulation (depression) of EPSPs
6) Confidence 0.42 Published 1996 Journal Anesthesiology Section Body Doc Link 8853094 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: A possible explanation for the neuropathic pain-related suppression of EPSPs is that the ACC was already sufficiently active at baseline as a result of neuropathic pain, and ATN stimulation could not further increase the already elevated level of ACC activity.
Negative_regulation (suppression) of EPSPs in ACC
7) Confidence 0.38 Published 2008 Journal Brain Res. Section Body Doc Link 18786516 Disease Relevance 0.08 Pain Relevance 0
Acetylcholine and norepinephrine, which are important thalamic modulators, have no effect on the efficacy of lemniscal EPSPs but reduce evoked inhibitory postsynaptic potentials and corticothalamic EPSPs.
Neg (no) Negative_regulation (reduce) of EPSPs
8) Confidence 0.37 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826059 Disease Relevance 0 Pain Relevance 0.25
Intracellular recordings from motoneurons clearly demonstrated a marked reduction in amplitude of the EPSPs before the block of conduction of presynaptic fibers and the block of invasion of the neuron soma by antidromic spike potential.
Negative_regulation (reduction) of EPSPs in neuron
9) Confidence 0.37 Published 1982 Journal Brain Res. Section Abstract Doc Link 6291710 Disease Relevance 0 Pain Relevance 0.58
The evoked EPSPs included a secondary depolarizing component, which appeared approximately 5 ms after the peak of the initial component and was voltage dependent, i.e. most prominent between -70 mV and -85 mV, while being greatly reduced or absent at more hyperpolarized levels.
Negative_regulation (reduced) of EPSPs
10) Confidence 0.37 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15548212 Disease Relevance 0 Pain Relevance 0.08
We demonstrate that during BS EPSPs were diminished by 44%, whereas inhibitory potentials were completely suppressed.
Negative_regulation (diminished) of EPSPs
11) Confidence 0.37 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19657037 Disease Relevance 0.08 Pain Relevance 0.34
The input resistance decreased during seizures but quickly recovered to control level after the paroxysms, whereas the amplitude of evoked EPSPs remained lower following seizures, generally for 2-12 min, suggesting that the decreased EPSPs were not due to an alteration of intrinsic response.
Negative_regulation (decreased) of EPSPs associated with convulsion
12) Confidence 0.37 Published 2008 Journal Epilepsia Section Abstract Doc Link 18031546 Disease Relevance 0.57 Pain Relevance 0.16
The glutamate receptor blocker 6-cyano-7-nitroquinoxaline-2,3-dione abolished the EPSPs evoked at resting membrane potentials.
Negative_regulation (abolished) of EPSPs associated with glutamate receptor
13) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396641 Disease Relevance 0 Pain Relevance 0.88
Ethanol 22, 44 and 66 mM all significantly decreased the EPSPs evoked by half-maximal stimulation to 80, 60 and 68% of control, respectively.
Negative_regulation (decreased) of EPSPs
14) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396641 Disease Relevance 0 Pain Relevance 0.73
We recently showed that opiate peptides reduced both excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) in NAcc neurons of a slice preparation, with naloxone (Nal) reversal (Yuan et al., 1992).
Negative_regulation (reduced) of EPSPs in neurons associated with nucleus accumbens, narcan and opiate
15) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396641 Disease Relevance 0 Pain Relevance 0.63
As ethanol actions mimic those of opiates in reducing EPSPs without effect on resting membrane potentials in the NAcc, we applied the opiate antagonist Nal together with ethanol.
Negative_regulation (reducing) of EPSPs associated with nucleus accumbens, antagonist, narcan and opiate
16) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8396641 Disease Relevance 0 Pain Relevance 0.85
Slow EPSPs evoked by MN stimulation (Takaki and Nakayama (1988) Brain Res., 442, 351-353) were also obtained in 5 Type 2/AH neurons and were irreversibly abolished by superfusion with capsaicin 10 microM.
Negative_regulation (abolished) of EPSPs in neurons associated with qutenza
17) Confidence 0.37 Published 1990 Journal Acta Med. Okayama Section Abstract Doc Link 1701955 Disease Relevance 0 Pain Relevance 0.26
Fast EPSPs were abolished by hexamethonium.
Negative_regulation (abolished) of EPSPs
18) Confidence 0.37 Published 1990 Journal Acta Med. Okayama Section Abstract Doc Link 1701955 Disease Relevance 0 Pain Relevance 0.22
Although acetylcholine and norepinephrine do not affect lemniscal synapses, the postsynaptic depolarization they produce on thalamocortical neurons serves to warrant the relay of lemniscal inputs at high-frequency rates by bringing the depressed lemniscal EPSPs close to firing threshold.
Negative_regulation (depressed) of EPSPs in synapses
19) Confidence 0.37 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826059 Disease Relevance 0 Pain Relevance 0.22
On the contrary, rectification of the membrane and the shunt of the EPSPs below -85 mV were clearly reduced by tetraethylammonium (TEA, 10-20 mM).
Negative_regulation (reduced) of EPSPs
20) Confidence 0.36 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2341867 Disease Relevance 0.05 Pain Relevance 0

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