INT15530

Context Info Confidence 0.39 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.84 Pain Relevance 0.16

small molecule metabolic process (FFAR1) plasma membrane (FFAR1) signal transducer activity (FFAR1)

Anatomy Link Frequency plasma 2 fat 2 skeletal muscle 2 FFAR1 (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 3 92.32 Opioid 1 80.80 Endogenous opioid 1 31.44 addiction 5 5.00 anesthesia 2 5.00 lidocaine 2 5.00 Immobilon 2 5.00 imagery 2 5.00 Pain 1 5.00 behavioral therapy 1 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 8 100.00 Obesity 5 100.00 Diabetes Mellitus 2 99.72 Mental Disorders 114 99.16 Obsessive-compulsive Disorder 10 5.00 Tics 10 5.00 Psychosis 10 5.00 Syndrome 7 5.00 Anxiety Disorder 7 5.00 Phobia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As it turns out, philosophers of free will frequently refer to mental disorders as conditions that compromise free will and reduce moral responsibility.

Positive_regulation (philosophers) of Gene_expression (philosophers) of free will associated with mental disorders

1) Confidence 0.39 Published 2010 Journal Theor Med Bioeth Section Abstract Doc Link PMC2975916 Disease Relevance 0.95 Pain Relevance 0

The infusion of synthetic human beta-endorphin (4.5 ng/kg/min) produced the following: (1) in normal-weight subjects, no significant change of plasma glucose and pancreatic hormones (insulin, C-peptide, and glucagon), a significant plasma free fatty acids (FFA) increase, and a suppression of glycerol plasma levels; (2) in obese subjects, significant increases of glucose, insulin, C-peptide, and glucagon, a progressive decline of circulating FFA, and no change in glycerol plasma levels.

Positive_regulation (increases) of Gene_expression (produced) of FFA in plasma associated with obesity

2) Confidence 0.09 Published 1992 Journal Metab. Clin. Exp. Section Abstract Doc Link 1736041 Disease Relevance 0.37 Pain Relevance 0.16

The impact of exercise on PDH regulation in skeletal muscle unrelated to the metabolic status of the cell and body may reflect that exercise can overcome potential inhibition of carbohydrate utilization present in resting skeletal muscle when circulating FFA levels are increased (2).

Positive_regulation (increased) of Gene_expression (levels) of FFA in skeletal muscle

3) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.23 Pain Relevance 0

Thus, although there was no effect of elevated FFA on PDHa activity at rest in the present study, maybe due to the overnight high-fat diet in both trials, elevated FFA levels have been shown to induce insulin resistance (31,32), and individuals with enhanced circulating FFA levels like type 2 diabetic subjects may experience FFA-mediated insulin resistance at rest (33), potentially in part because of FFA-induced downregulation of PDH (1).

Positive_regulation (experience) of Gene_expression (resistance) of FFA-mediated in fat associated with diabetes mellitus and insulin resistance

4) Confidence 0.05 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.30 Pain Relevance 0

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