INT15546

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Context Info
Confidence 0.81
First Reported 1988
Last Reported 2001
Negated 2
Speculated 1
Reported most in Abstract
Documents 70
Total Number 71
Disease Relevance 4.23
Pain Relevance 10.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
colon 9
vasculature 4
neuronal 3
ileum 2
endocrine cells 2
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 66 100.00 Very High Very High Very High
antagonist 15 100.00 Very High Very High Very High
Catecholamine 9 100.00 Very High Very High Very High
substance P 16 99.84 Very High Very High Very High
Enkephalin 4 99.72 Very High Very High Very High
tetrodotoxin 48 99.46 Very High Very High Very High
Neurotransmitter 20 99.22 Very High Very High Very High
Cholecystokinin 26 99.20 Very High Very High Very High
Spinal cord 12 98.80 Very High Very High Very High
noradrenaline 2 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Frailty 12 98.94 Very High Very High Very High
Shock 10 98.94 Very High Very High Very High
Vibrio Infection 16 98.24 Very High Very High Very High
Pancreatitis 4 96.60 Very High Very High Very High
Congenital Anomalies 3 91.12 High High
Diarrhoea 4 89.44 High High
Cryptosporidiosis 6 87.12 High High
Constipation 3 78.76 Quite High
Ileus 3 78.04 Quite High
Abdominal Pain 3 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urethane anaesthesia did not reduce PYY release induced by the intraduodenal meal.
Localization (release) of PYY
1) Confidence 0.81 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
PYY release induced by the intraduodenal meal peaked at 60min and lasted more than 120min.
Localization (release) of PYY
2) Confidence 0.81 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
Because PYY and enteroglucagon are both found in colonic endocrine cells, these results suggest that the release of PYY and enteroglucagon are mediated by specific secretagogues and not simply caused by noxious effects of the agonists.
Localization (release) of PYY in endocrine cells associated with agonist
3) Confidence 0.80 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2596607 Disease Relevance 0 Pain Relevance 0.20
Further, these studies suggest that release of PYY is mediated by cAMP-dependent pathways.
Localization (release) of PYY
4) Confidence 0.79 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 7694325 Disease Relevance 0.15 Pain Relevance 0.22
Tetrodotoxin did not modify the bombesin-induced release of PYY, GLP-1, and NT.
Localization (release) of PYY associated with tetrodotoxin
5) Confidence 0.78 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.30
The two cosynthesized peptides, PYY and GLP-1, appear to be cosecreted in the conditions of the present study.
Localization (cosecreted) of PYY
6) Confidence 0.78 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.21
Similarly, bombesin (10(-7) M) induced a marked biphasic release of PYY and GLP-1.
Localization (release) of PYY
7) Confidence 0.78 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.29
The muscarinic cholinergic agonist bethanechol at a concentration of 10(-4) M provoked a biphasic release of PYY, GLP-1, and NT, consisting of an early peak followed by a sustained response.
Localization (release) of PYY associated with agonist
8) Confidence 0.78 Published 1995 Journal Endocrinology Section Abstract Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.27
Postprandial PYY release was suppressed or strongly decreased by caecocolonectomy, truncal vagotomy, tetrodotoxin, hexamethonium, sensory denervation by perivagal capsaicin, and by the NO-synthase inhibitor L-N-arginine methyl ester, while atropine, adrenergic blockers, antagonists of type-A or type-B cholecystokinin (CCK) receptors or bombesin receptors had no effect.
Localization (release) of PYY associated with tetrodotoxin, qutenza, antagonist and cholecystokinin
9) Confidence 0.76 Published 1997 Journal Pflugers Arch. Section Abstract Doc Link 9049141 Disease Relevance 0 Pain Relevance 0.32
These findings suggest that PYY acts as an enhancer of sodium chloride and water absorption and as an antagonist to VIP-induced secretion in the colon.
Localization (secretion) of PYY in colon associated with antagonist
10) Confidence 0.75 Published 1992 Journal Experientia Section Abstract Doc Link 1737576 Disease Relevance 0 Pain Relevance 0.12
Results suggest that the antisecretory effects of PYY are mediated by inhibition of prostaglandin I2 induction of enteric nerves.
Localization (antisecretory) of PYY in enteric nerves
11) Confidence 0.74 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353387 Disease Relevance 0.21 Pain Relevance 0.12
General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.
Localization (secretions) of PYY
12) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.12
Additionally, GLP-1 and PYY secretions are positively modulated by alpha1-receptor stimulation and inhibited by alpha2-receptor activation upon beta-receptor occupation.
Localization (secretions) of PYY
13) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.23
Because terbutaline but not dobutamine or BRL 37,344 (10(-5) M) induced significant GLP-1 and PYY secretions (135+/-30 and 305+/-39 fmol/8 min respectively), isoproterenol-induced secretions are suggested to result mainly from stimulation of the beta2-isoreceptor type.
Localization (secretions) of PYY
14) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.24
The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min induced a transient release of GLP-1 and PYY (integrated release over the 8 min of the peak secretion: 38+/-16 and 214+/-69 fmol for GLP-1 and PYY respectively, P<0.05).
Localization (release) of PYY associated with agonist
15) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.16
When co-infused with 10(-6) M or 10(-7) M isoproterenol, 10(-7) M phenylephrine raised GLP-1 release to 174+/-53 and 108+/-28 fmol/8 min respectively (vs 38+/-16 and 35+/-10 fmol/8 min for isoproterenol alone, P<0.05) whereas PYY secretion was not significantly increased.
Localization (secretion) of PYY
16) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.26
The beta-adrenergic agonist isoproterenol (10(-6) M) infused for 30 min induced a transient release of GLP-1 and PYY (integrated release over the 8 min of the peak secretion: 38+/-16 and 214+/-69 fmol for GLP-1 and PYY respectively, P<0.05).
Localization (release) of PYY associated with agonist
17) Confidence 0.71 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.16
Hexamethonium suppressed PYY release induced by the intraduodenal meal, but did not change PYY release induced by glucose or oleic acid in the colon.
Localization (release) of PYY in colon
18) Confidence 0.71 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
These results suggest that two mechanisms at least contribute to PYY release in the rat.
Localization (release) of PYY
19) Confidence 0.71 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0
The undigested meal induced no release of PYY over a 120-min period when administered into the colon.
Neg (no) Localization (release) of PYY in colon
20) Confidence 0.71 Published 1995 Journal Pflugers Arch. Section Abstract Doc Link 8584419 Disease Relevance 0 Pain Relevance 0

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