INT155466

Context Info Confidence 0.38 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.35 Pain Relevance 1.01

nucleus (Tfdp1) cell cycle (Tfdp1) DNA binding (Tfdp1) transcription factor binding (Tfdp1)

Anatomy Link Frequency spinal cord 1 Tfdp1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 10 99.44 Dorsal horn neuron 1 96.68 Spinal cord 2 94.96 Dorsal horn 1 91.76 cOX1 3 73.16 analgesia 1 63.88 antagonist 1 61.48 COX2 2 25.00

Disease Link Frequency Relevance Heat Pain 8 99.44 Targeted Disruption 4 85.24 Nociception 4 75.00 Toxicity 1 65.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Deficiency of either EP2 or DP1 was associated with increased formalin-evoked flinching responses and c-Fos IR in dorsal horn neurons suggesting facilitated spinal cord pain reflex circuity.

Negative_regulation (Deficiency) of DP1 in spinal cord associated with pain, dorsal horn neuron and spinal cord

1) Confidence 0.38 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938093 Disease Relevance 1.35 Pain Relevance 1.01

General Comments

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