INT155662

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
skin 2
microglia 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cancer pain 3 99.74 Very High Very High Very High
Spinal cord 3 98.24 Very High Very High Very High
Peripheral nerve injury 3 96.04 Very High Very High Very High
Hyperalgesia 1 94.64 High High
Lasting pain 2 92.00 High High
Dorsal horn neuron 1 90.60 High High
nMDA receptor 1 89.68 High High
Inflammation 2 89.52 High High
Inflammatory response 1 80.72 Quite High
Pain 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer Pain 3 99.74 Very High Very High Very High
Nervous System Injury 3 96.04 Very High Very High Very High
Skin Cancer 4 94.84 High High
Hyperalgesia 1 94.64 High High
Pain 3 92.00 High High
INFLAMMATION 3 89.52 High High
Breast Cancer 1 85.96 High High
Lung Cancer 1 85.24 High High
Cancer 4 81.12 Quite High
Neuropathic Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Positive_regulation (increased) of Localization (release) of P2X in skin associated with cancer pain
1) Confidence 0.47 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.11 Pain Relevance 0.39
Furthermore, ATP stimulation is unable to stimulate BDNF release from P2X(4)-deficient mice microglia in primary cultures.
Neg (unable) Positive_regulation (stimulate) of Localization (release) of P2X in microglia
2) Confidence 0.39 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.81 Pain Relevance 0.87

General Comments

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