INT155696

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 8.54
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
macrophages 1
endothelial cells 1
skin 1
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 8 99.80 Very High Very High Very High
Kinase C 27 99.68 Very High Very High Very High
metalloproteinase 151 99.56 Very High Very High Very High
Inflammation 102 87.44 High High
antagonist 6 84.96 Quite High
dexamethasone 16 83.76 Quite High
cytokine 82 77.20 Quite High
chemokine 5 74.16 Quite High
tolerance 40 67.20 Quite High
Eae 12 60.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 397 98.52 Very High Very High Very High
Obesity 99 98.24 Very High Very High Very High
Cancer 209 97.58 Very High Very High Very High
Adhesions 50 96.92 Very High Very High Very High
Cardiovascular Disease 37 96.68 Very High Very High Very High
Death 127 94.72 High High
Leukemia 9 94.32 High High
Insulin Resistance 83 93.92 High High
Metabolic Syndrome 51 93.44 High High
Endometrial Cancer 100 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate that lercanidipine can suppress the proliferation of VSMCs via inhibiting cellular ROS, Ras-MEK1/2-ERK1/2, and PI3K-Akt pathways, and suggesting that it may have therapeutic relevance in the prevention of human restenosis.
Gene_expression (pathways) of PI3K associated with cardiovascular disease
1) Confidence 0.65 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.36 Pain Relevance 0
Hair samples, skin punch biopsies, and tumor biopsies obtained before and after drug administration demonstrated decreased phosphorylation of various targets in the PI3K pathway, including AKT.
Gene_expression (pathway) of PI3K in skin associated with cancer
2) Confidence 0.43 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.29 Pain Relevance 0
XL765, a dual PI3K and mTOR inhibitor
Gene_expression (XL765) of PI3K
3) Confidence 0.43 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.54 Pain Relevance 0
These results demonstrate that the ability of PTEN to negatively regulate the PI 3-K/Akt/NF-?
Gene_expression (/) of PI 3-K
4) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0
The present results confirm that PI 3-K inhibition with Wortmannin and LY294002 induce apoptosis (Fig. 1).
Neg (inhibition) Gene_expression (inhibition) of PI 3-K associated with apoptosis
5) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.80 Pain Relevance 0
These results demonstrate that the ability of PTEN to negatively regulate the PI 3-K/Akt/NF-?
Gene_expression (/) of PI 3-K
6) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0
As hypothesized, the results demonstrate that PI 3-K inhibition results in the reduction I?
Neg (inhibition) Gene_expression (inhibition) of PI 3-K
7) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.38 Pain Relevance 0
PTEN is a crucial phosphatase involved in the regulation of Akt phosphorylation: the presence of an active PTEN protein blocks Akt phosphorylation by the dephosphorylation of PI 3-K product, PIP3 [45].
Gene_expression (product) of PI 3-K
8) Confidence 0.27 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0.04
This effect may be mediated by the ERK1/2 and PKC, but not PI3K pathway 62.
Gene_expression (pathway) of PI3K
9) Confidence 0.25 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.41 Pain Relevance 0
Regulation of MMP-12 activity and gene expression by MAPKs, PI3-K and corticosteroid
Gene_expression (expression) of PI3-K associated with corticosteroid and metalloproteinase
10) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.62
PPAR- is expressed in endothelial cells, and its ligands have been reported to enhance NO production, possibly by stimulating the PI3K pathway and hence expression of eNOS (Kim et al 2002).
Gene_expression (expression) of PI3K in endothelial cells
11) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.83 Pain Relevance 0.06
Second, insulin is a vasodilator stimulating expression of eNOS through the phosphatidylinositol 3-kinase (PI3K) pathway (Zeng et al 2000).
Gene_expression (expression) of PI3K
12) Confidence 0.18 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.84 Pain Relevance 0.08
In addition, it accelerates cholesteryl ester accumulation in human monocyte-derived macrophages by increasing ACAT-1 expression via JAK2 and PI3K, thereby suppressing cholesterol efflux [29].
Gene_expression (expression) of PI3K in macrophages
13) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.14 Pain Relevance 0.14
The relevance of trophic support, mainly NGF and IGF-1, and other growth factor signaling through trk receptors and activation of PI3K/Akt and PKC, is also linked to the key role played by GSK-3?
Gene_expression (/) of PI3K associated with kinase c
14) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.04 Pain Relevance 0.08
Down-regulation of PI3K/Akt results in active GSK-3?
Gene_expression (/) of PI3K
15) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.84 Pain Relevance 0
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Gene_expression (p85aPI3K) of p85aPI3K
16) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0

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