INT155702

Context Info Confidence 0.48 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.20

pigmentation (MC1R) extracellular region (CAMP) plasma membrane (MC1R) signal transducer activity (MC1R)

Anatomy Link Frequency pigmentation 2 MC1R (Homo sapiens) CAMP (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 2 100.00 antagonist 2 25.00

Disease Link Frequency Relevance Heat Microphthalmia 2 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins alpha-MSH and ACTH.

melanocortin-1 receptor Positive_regulation (induction) of cAMP in pigmentation associated with melanocortin 1 receptor

1) Confidence 0.48 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0 Pain Relevance 0.10

To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins alpha-MSH and ACTH.

MC1-R Positive_regulation (induction) of cAMP in pigmentation associated with melanocortin 1 receptor

2) Confidence 0.48 Published 2009 Journal Endocrinology Section Abstract Doc Link 18974267 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.