INT15594

Context Info Confidence 0.26 First Reported 1991 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.96 Pain Relevance 1.14

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha) carbohydrate metabolic process (Ldha) cytoplasm (Ldha)

Anatomy Link Frequency plasma 1 lung 1 Ldha (Mus musculus)

Pain Link Frequency Relevance Heat cocaine 12 99.02 Buprenorphine 7 98.80 narcan 3 89.56 Inflammation 9 5.00 Inflammatory response 2 5.00 anesthesia 1 5.00 Pain 1 5.00 abdominal pain 1 5.00 isoflurane 1 5.00

Disease Link Frequency Relevance Heat Weight Loss 11 96.60 Jaundice 1 94.68 Pain 1 92.36 Immunization 2 90.84 Infection 40 85.04 Toxicity 4 80.72 Shock 5 73.12 Acute Liver Failure 1 50.00 Influenza Virus Infection 30 47.00 Respiratory Syncytial Virus 3 38.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When tested 0.5, 1, 2, 4, 8 and 24 hrs after cocaine administration, sublethal dose of cocaine (80 mg/kg ip) injection resulted in significant increase in the plasma lactate dehydrogenase (LDH) levels.

Positive_regulation (increase) of plasma lactate dehydrogenase in plasma associated with cocaine

1) Confidence 0.26 Published 1991 Journal Life Sci. Section Abstract Doc Link 1745104 Disease Relevance 0.30 Pain Relevance 1.14

The lack of any lung damage associated with the PCN treatment was further supported by the absence of any increase in the levels of serum albumin (Figure 3C) and lactate dehydrogenase (Figure 3D) recovered in the BALF of these mice at this time and the absence of any weight loss during the PCN treatment regimen (data not shown).

Positive_regulation (increase) of lactate dehydrogenase in lung associated with weight loss

2) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.48 Pain Relevance 0

INVESTIGATIONS: The activities of SGOT (756 U/I), SGPT (1450 U/I). gamma GT (164 U/I) and lactate dehydrogenase (539 U/I) as well as total bilirubin level (7.5 mg/dl) were elevated.

Positive_regulation (elevated) of lactate dehydrogenase

3) Confidence 0.05 Published 1997 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9213536 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.