INT15606

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 9.16
Pain Relevance 2.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FSHB) small molecule metabolic process (FSHB) extracellular region (FSHB)
cellular nitrogen compound metabolic process (FSHB) cytoplasm (FSHB)
Anatomy Link Frequency
testis 3
thyroid 2
pituitary 2
pituitary gland 2
gonadal 1
FSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 17 99.36 Very High Very High Very High
narcan 13 99.08 Very High Very High Very High
Central nervous system 9 95.28 Very High Very High Very High
Opioid 7 92.16 High High
abdominal pain 5 92.00 High High
Enkephalin 5 89.64 High High
agonist 55 83.28 Quite High
Dopamine 9 82.96 Quite High
opiate 3 77.84 Quite High
fibrosis 112 72.48 Quite High
Disease Link Frequency Relevance Heat
Adenoma 121 99.98 Very High Very High Very High
Cancer 104 99.62 Very High Very High Very High
Heart Rate Under Development 24 97.44 Very High Very High Very High
Arrhythmias 2 Under Development 54 96.36 Very High Very High Very High
Precocious Puberty 4 95.52 Very High Very High Very High
Pituitary Cancer 67 92.68 High High
Abdominal Pain 5 92.00 High High
Cryptorchidism 8 89.72 High High
Adrenal Cancer 138 87.20 High High
Follicular Cyst 5 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This case is remarkable because the ovarian hyperstimulation related to the FSH-secreting adenoma was not associated with high levels of serum estradiol, probably due to insufficient LH production by the normal pituitary.
Localization (secreting) of FSH in pituitary associated with adenoma
1) Confidence 0.78 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.60 Pain Relevance 0.07
Stimulation with TRH (both in vivo preoperatively and in vitro study of the excised tumor) had no effect on FSH secretion from the adenoma.
Localization (secretion) of FSH associated with adenoma and cancer
2) Confidence 0.78 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.78 Pain Relevance 0.13
We report a unique case of a 28-yr-old woman with a gonadotroph adenoma secreting FSH, presented with ovarian hyperstimulation, without elevation of serum estradiol.
Localization (secreting) of FSH in gonadotroph associated with adenoma
3) Confidence 0.78 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.35 Pain Relevance 0.09
The excised adenoma tissue exhibited intense immunostaining for FSH and secreted this hormone to culture medium.
Localization (secreted) of FSH associated with adenoma
4) Confidence 0.68 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.77 Pain Relevance 0.14
Estradiol did not suppress FSH release from cultured adenoma cells.
Localization (release) of FSH associated with adenoma
5) Confidence 0.68 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11502789 Disease Relevance 0.73 Pain Relevance 0.13
Micro- to picomolar amounts of Met-Enk increased FSH-induced P secretion up to 186.9 +/- 35.1% (+/- SEM).
Localization (secretion) of FSH
6) Confidence 0.59 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2944912 Disease Relevance 0 Pain Relevance 0.46
These data provide evidence for a dose-dependent naloxone-reversible synergistic action of Met-Enk and FSH on P secretion by cultured granulosa cells.
Localization (secretion) of FSH in granulosa cells associated with narcan
7) Confidence 0.59 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2944912 Disease Relevance 0 Pain Relevance 0.46
The elevation in serum testosterone levels in our patient was secondary to co-secretion of LH and FSH by the adenoma.
Localization (secretion) of FSH associated with adenoma
8) Confidence 0.24 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2270282 Disease Relevance 0.80 Pain Relevance 0.03
It was found, however, that [D-pGlu1, D-Phe2, D-Trp3,6]-GnRH, a specific GnRH receptor antagonist, did reduce hBE-induced LH and FSH release (p less than 0.05).
Localization (release) of FSH associated with antagonist
9) Confidence 0.21 Published 1985 Journal Peptides Section Abstract Doc Link 2417204 Disease Relevance 0 Pain Relevance 0.53
The majority of TSHomas (72%) secrete TSH alone, but 16% also secrete growth hormone (GH), 11% secrete prolactin (PRL), and 1% secretes LH or FSH [6].
Localization (secretes) of FSH
10) Confidence 0.21 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2270282 Disease Relevance 0.80 Pain Relevance 0
The majority of TSHomas (72%) secrete TSH alone, but 16% also secrete growth hormone (GH), 11% secrete prolactin (PRL), and 1% secretes LH or FSH [6].
Localization (secrete) of FSH
11) Confidence 0.21 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2270282 Disease Relevance 0.82 Pain Relevance 0
Grumbach [14] noted that because levels of FSH, LH, and sex steroid secretion are low in childhood and male infant levels of testosterone increase during the second week, reaching a maximum at 4 to 10 weeks and declining to low levels by the time the child is approximately 6 months old, in the scenario of micropenis with or without cryptorchidism, it is imperative to exploit the window of opportunity in order to establish the diagnosis hypogonadotropic hypogonadism.
Localization (secretion) of FSH associated with hypogonadotropic hypogonadism and cryptorchidism
12) Confidence 0.16 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2963131 Disease Relevance 0.69 Pain Relevance 0
The former includes GH secreting (cell) adenomas (abbreviated as GHomas), prolactin (PRL) secreting (cell) adenomas (PRLomas), TSH secreting (cell) adenomas (TSHomas), ACTH secreting (cell) adenomas (ACTHomas), and FSH secreting (cell) adenomas (FSHomas) (Fig. 1).
Localization (secreting) of FSH associated with adenoma
13) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.29 Pain Relevance 0
This may reflect the need to differentially synthesize and secrete FSH and LH at different times during reproductive cycles to allow orderly follicular maturation and ovulation.
Localization (secrete) of FSH
14) Confidence 0.13 Published 1991 Journal Recent Prog. Horm. Res. Section Abstract Doc Link 1745819 Disease Relevance 0 Pain Relevance 0.16
The importance of this estrogen-induced increase in FSH secretion is not known: it has not been established whether estradiol acting directly at the level of the testis is sufficient to produce qualitative spermatogenesis in hpg mice or whether the effects of estradiol in inducing spermatogenesis are more indirect, occurring via the rise in FSH production.
Localization (secretion) of FSH in testis
15) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.11 Pain Relevance 0
If, however, combined estradiol and rhFSH treatment were to be only as efficacious as would be expected from a higher rhFSH dose (i.e. an additive effect) then we would conclude that estradiol most likely acts via stimulation of FSH secretion.


Localization (secretion) of FSH
16) Confidence 0.09 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0.08 Pain Relevance 0
In this situation, the hypothalamic GnRH pulse generator prematurely resumes pulsatile GnRH secretion leading to increased LH and FSH secretion resulting in increased gonadal steroid production.
Localization (secretion) of FSH in gonadal
17) Confidence 0.09 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 1.13 Pain Relevance 0.04
The aim of the current studies was to investigate whether these effects of estradiol are direct effects in the testis, or indirect actions via paradoxical stimulation of FSH secretion from the pituitary gland.


Localization (secretion) of FSH in pituitary gland
18) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
As ERalpha receptor is abundantly expressed in the pituitary gland of hpg mice, and estradiol did not exert effects on testis development over and above those of FSH, we conclude that the action of estradiol on testis development in hpg mice is predominantly via the stimulation of pituitary FSH release.



Localization (release) of FSH in testis
19) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Given the qualitative and quantitative similarity of the effects of estradiol and rhFSH that we observed, we conclude that the primary action of estradiol on testis function is indirect, via the stimulation of FSH release, in the hpg mouse experimental model.
Localization (release) of FSH in testis
20) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

General Comments

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