INT156084

Context Info Confidence 0.02 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.30

cytoplasm (PTGS2, AKR1C3) nucleus (PTGS2, AKR1C3) small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) intracellular (AKR1C3) enzyme binding (PTGS2)

PTGS2 (Homo sapiens) AKR1C3 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 3 92.16 Inflammation 1 75.00

Disease Link Frequency Relevance Heat INFLAMMATION 2 79.88 Reprotox - General 1 4 76.72 Breast Cancer 1 48.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using known structure-activity relationships for the inhibition of PGHS-1 and PGHS-2 by indole acetic acids we obtained N-(4-chlorobenzoyl)-melatonin as a specific AKR1C3 inhibitor (K(I)=6.0muM) that does not inhibit PGHS-1, PGHS-2, AKR1C1, or AKR1C2.

PGHS-2 Neg (inhibit) Binding (inhibit) of AKR1C3

1) Confidence 0.02 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19010312 Disease Relevance 0.31 Pain Relevance 0.30

General Comments

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