INT156175

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.86
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv4) cilium (Trpv4) transmembrane transport (Trpv4)
Anatomy Link Frequency
growth cones 2
sensory nerves 2
vascular endothelium 2
Trpv4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Taxol 60 99.58 Very High Very High Very High
Kinase C 8 99.00 Very High Very High Very High
Hyperalgesia 11 89.76 High High
imagery 24 77.44 Quite High
agonist 12 69.76 Quite High
Inflammation 3 60.20 Quite High
Pain 27 56.32 Quite High
member 8 1 49.04 Quite Low
dorsal root ganglion 32 27.76 Quite Low
qutenza 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Stress 10 99.66 Very High Very High Very High
Hyperalgesia 11 67.84 Quite High
Adhesions 6 62.40 Quite High
Increased Venous Pressure Under Development 4 60.56 Quite High
INFLAMMATION 3 60.20 Quite High
Pressure Volume 2 Under Development 4 57.20 Quite High
Ganglion Cysts 32 27.76 Quite Low
Nociception 28 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
Neuropathic Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell culture and in vivo studies demonstrate that an FSS- or a 4alphaPDD-induced activation of Trpv4 leads to an active proliferation of vascular cells and finally triggers collateral growth.
Positive_regulation (induced) of Positive_regulation (activation) of Trpv4 associated with stress
1) Confidence 0.50 Published 2009 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19017361 Disease Relevance 0.38 Pain Relevance 0
To detect the roles of various vasodilating factors released by vascular endothelium in the hypotensive effect induced by TRPV4 activation, the corresponding inhibitors/blockers, including indomethacin (a cyclooxygenase inhibitor, 10 mg/kg, i.v.), Nomega-nitro-L-arginine (L-NA, a nitric oxide synthase inhibitor, 20 mg/kg, i.v.), apamin [a blocker of small conductance Ca2+-activated K+ (MaxiK) channels, 50 microg/kg, i.v.] combined with charybdotoxin (a blocker of intermediate and large conductance MaxiK channels, 50 microg/kg, i.v.), were used at various time before 4alpha-PDD injection.
Positive_regulation (induced) of Positive_regulation (activation) of TRPV4 in vascular endothelium
2) Confidence 0.49 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: Our data show that the hypotensive effect induced by TRPV4 activation attributes to, at least in part, activation of MaxiK channels and CGRP receptors upon CGRP release from sensory nerves.


Positive_regulation (induced) of Positive_regulation (activation) of TRPV4 in sensory nerves
3) Confidence 0.49 Published 2010 Journal J. Hypertens. Section Body Doc Link 19996988 Disease Relevance 0 Pain Relevance 0
Activation of TRPV4 results in fast retraction of growth cones in F11 cell
Positive_regulation (results) of Positive_regulation (Activation) of TRPV4 in growth cones
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0.18 Pain Relevance 0.07
Stabilization of microtubules by Taxol reduces Ca2+-influx through TRPV4 activation
Positive_regulation (through) of Positive_regulation (activation) of TRPV4 associated with taxol
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906515 Disease Relevance 0 Pain Relevance 0.12
Thus PKC, and possibly PKA, phosphorylate TRPV4 at Ser824 leading to the enhancement of TRPV4 channel function.
Positive_regulation (leading) of Positive_regulation (enhancement) of TRPV4 associated with kinase c
6) Confidence 0.40 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20043876 Disease Relevance 0.24 Pain Relevance 0.61

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