INT156213

Context Info Confidence 0.39 First Reported 2007 Last Reported 2011 Negated 3 Speculated 0 Reported most in Body Documents 6 Total Number 9 Disease Relevance 7.50 Pain Relevance 1.54

extracellular region (Cort)

Anatomy Link Frequency plasma 2 Cort (Mus musculus)

Pain Link Frequency Relevance Heat fluoxetine 4 100.00 isoflurane 5 94.68 depression 42 92.88 Eae 12 92.80 cytokine 2 84.56 orphanin 4 75.00 anesthesia 2 72.16 corticosteroid 2 67.92 Serotonin 4 44.52 Pain 6 42.16

Disease Link Frequency Relevance Heat Stress 345 99.36 Alopecia Areata 8 99.36 Anxiety Disorder 50 96.08 Targeted Disruption 241 94.96 Depression 54 92.88 Necrosis 1 81.52 Cancer 1 81.16 Pain 6 42.16 Hypersensitivity 12 37.80 Sprains And Strains 53 31.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In agreement with these predictions, both AFR controls and H-CORT mice showed a differential inter-individual variation compared to L-CORT subjects.

Regulation (controls) of CORT

1) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2000350 Disease Relevance 0 Pain Relevance 0.03

Experiment 3 found that group-housed females had higher baseline corticosterone (CORT) levels than isolated females and fluoxetine had no effect on CORT levels.

Neg (no) Regulation (effect) of CORT associated with fluoxetine

2) Confidence 0.38 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19819265 Disease Relevance 0.70 Pain Relevance 0.50

Additionally, a gender difference was evident; females displayed a greater change of plasma CORT levels than males.

Regulation (change) of CORT in plasma

3) Confidence 0.24 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19457551 Disease Relevance 0.16 Pain Relevance 0.42

Experiment 3 found that group-housed females had higher baseline corticosterone (CORT) levels than isolated females and fluoxetine had no effect on CORT levels.

Neg (no) Regulation (effect) of CORT associated with fluoxetine

4) Confidence 0.23 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19819265 Disease Relevance 0.69 Pain Relevance 0.49

In addition, plasma hormones levels were only measured at one time point in our studies so any incremental change in CORT levels may have been missed.

Regulation (change) of CORT in plasma

5) Confidence 0.23 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.96 Pain Relevance 0

AA mice had significantly blunted CORT and ACTH responses to acute ether stress (physiological stressor) and a deficit in habituation to repeated restraint stress (psychological stressor).

Regulation (responses) of CORT associated with stress and alopecia areata

6) Confidence 0.14 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 1.10 Pain Relevance 0.10

Secondly, with the exception of the ACTH response to repeated, severe restraint, the ACTH and CORT responses to acute or repeated stress are of equivalent magnitude.

Regulation (responses) of CORT associated with stress

7) Confidence 0.10 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.36 Pain Relevance 0

No adaptation in CORT responses was observed in Avpr1b or wild-type mice following any repeated stress paradigm.

Neg (No) Regulation (responses) of CORT associated with stress

8) Confidence 0.10 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.68 Pain Relevance 0

It is important to recognise that the CORT response to ACTH saturates at low circulating ACTH levels (Dallman et al. 2002).

Regulation (response) of CORT

9) Confidence 0.10 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.85 Pain Relevance 0

General Comments

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