INT156316

Context Info Confidence 0.05 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.81 Pain Relevance 0.10

lipid binding (Apoc2) transport (Apoc2) extracellular space (Apoc2) extracellular region (Apoc2) lipid metabolic process (Apoc2)

Anatomy Link Frequency CII 3 Apoc2 (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 3 98.12

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 3 100.00 Pancreatitis 9 98.80 Calcification 3 75.00 Steatorrhea 3 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BACKGROUND: The factors that whether and how genes involving lipid metabolism including lipoprotein lipase (LPL) and apolipoprotein CII (apo CII) influence occurrence of acute attack of pancreatitis and chronic pancreatitis is not clear.

apo CII Binding (metabolism) of in CII associated with pancreatitis, chronic pancreatitis and disorder of lipid metabolism

1) Confidence 0.05 Published 2009 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 19034041 Disease Relevance 0.52 Pain Relevance 0.10

CONCLUSIONS: This is the first complete genetic study analyzing the association of LPL and apo CII mutation in a HLP population.

apo CII mutation Spec (analyzing) Binding (association) of in CII

2) Confidence 0.05 Published 2009 Journal J. Clin. Gastroenterol. Section Body Doc Link 19034041 Disease Relevance 0 Pain Relevance 0

GOALS: The aim of this study was to determine the association of LPL and apo CII genes with acute attack of pancreatitis and chronic pancreatitis in patients with hyperlipidemic pancreatitis (HLP) and hypertriglyceridemia (HTG).

apo CII Binding (association) of in CII

3) Confidence 0.05 Published 2009 Journal J. Clin. Gastroenterol. Section Body Doc Link 19034041 Disease Relevance 0.29 Pain Relevance 0

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