INT156381

From wiki-pain
Revision as of 22:35, 20 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0.86
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Dlg4) cytoplasm (Grin1, Dlg4) protein complex assembly (Dlg4)
enzyme binding (Grin1) response to stress (Dlg4)
Anatomy Link Frequency
brain 1
Grin1 (Rattus norvegicus)
Dlg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 5 100.00 Very High Very High Very High
Morphine 45 99.58 Very High Very High Very High
Neurobehavioral 5 98.72 Very High Very High Very High
Opioid 5 98.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 15 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits.
N-methyl-D-aspartate receptor Binding (complex) of postsynaptic density 95 associated with cognitive disorder, nmda receptor and morphine
1) Confidence 0.39 Published 2009 Journal Neuroscience Section Title Doc Link 19041927 Disease Relevance 0.16 Pain Relevance 0.45
These results are particularly important for a better understanding of certain opioid-mediated neurobehavioral cognitive changes in offspring associated with altered protein interaction between PSD-95 and NMDAR subunits within the developing brain.
NMDAR Binding (interaction) of PSD-95 in brain associated with cognitive disorder, neurobehavioral and opioid
2) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.23 Pain Relevance 0.64
Furthermore, the protein interaction of the synaptic complex between the PSD-95 and NMDAR subunit, as indicated by coimmunoprecipitation, was less in prenatal morphine samples than in vehicle controls (P14 and P45).
NMDAR subunit Binding (interaction) of PSD-95 associated with morphine
3) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.15 Pain Relevance 0.78
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
NR1 Binding (association) of PSD-95 associated with cognitive disorder and morphine
4) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.52
In this study, we determined whether prenatal morphine exposure altered the synaptic complex association between PSD-95 and three major NMDAR subunits (NR1, NR2A, and NR2B), at the mRNA and protein levels, within the hippocampal CA1 subregion (an important integration area for mammalian learning and memory) of rat offspring along with the performance of long-term cognitive functions.
NMDAR Binding (association) of PSD-95 associated with cognitive disorder and morphine
5) Confidence 0.33 Published 2009 Journal Neuroscience Section Abstract Doc Link 19041927 Disease Relevance 0.17 Pain Relevance 0.51

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox