INT156641

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.19
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CNOT4) RNA binding (CNOT4) nucleus (CNOT4)
ligase activity (CNOT4) cytoplasm (CNOT4)
Anatomy Link Frequency
platelet 1
reticulum 1
CNOT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 140 95.28 Very High Very High Very High
cINOD 7 94.24 High High
cva 9 91.40 High High
adenocard 2 69.92 Quite High
addiction 5 61.52 Quite High
Nicotine 18 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 9 98.40 Very High Very High Very High
Stress 168 97.20 Very High Very High Very High
Starvation 2 93.80 High High
Stomach Cancer 1 92.88 High High
Stroke 16 91.40 High High
Hypoxia 41 90.16 High High
Hemorrhage 1 89.44 High High
Cancer 90 86.80 High High
Apoptosis 50 78.20 Quite High
INFLAMMATION 17 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.
Positive_regulation (activating) of factor 4 in reticulum associated with stress
1) Confidence 0.07 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.79 Pain Relevance 0.32
-phosphorylation the translation of most mRNAs is inhibited, but paradoxically the translation of activating transcription factor 4 (ATF4) is increased.
Positive_regulation (activating) of factor 4
2) Confidence 0.05 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.92 Pain Relevance 0
Relative to placebo administration there was a statistically significant increase in platelet factor 4, ?
Positive_regulation (increase) of factor 4 in platelet
3) Confidence 0.04 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.65 Pain Relevance 0.52
phosphorylation promotes the induction of activating transcription factor 4 (ATF4) through a mechanism that relies upon unique features in its 5' untranslated region [54].
Positive_regulation (induction) of factor 4
4) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.42 Pain Relevance 0.03
phosphorylation promotes the induction of activating transcription factor 4 (ATF4) through a mechanism that relies upon unique features in its 5' untranslated region [54].
Positive_regulation (activating) of factor 4
5) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.03

General Comments

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