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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
Caco-2 1
EGF (Homo sapiens)
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 96.72 Very High Very High Very High
cINOD 6 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nerve Sheath Neoplasms 22 95.76 Very High Very High Very High
Apoptosis 37 81.20 Quite High
Watson Syndrome 19 65.80 Quite High
Cancer 16 55.20 Quite High
Reprotox - General 1 2 39.28 Quite Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Familial Adenomatous Polyposis 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the role of the extracellular signal regulated kinases (ERK) in 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3))-induced gene expression in the differentiated Caco-2 cells. 1,25(OH)(2)D(3)-regulated expression of the 25-hydroxyvitamin D, 24-hydroxylase (CYP24) gene (both natural gene and promoter construct) was strongly modulated by altering ERK activity (i.e., reduced by MEK inhibitors and dominant negative (dn) ERK1 and ERK2, activated by epidermal growth factor) but ERK inhibition had no effect on 1,25(OH)(2)D(3)-regulated expression of the transient receptor potential cation channel, subfamily V, member 6 (TRPV6).
epidermal growth factor Positive_regulation (activated) of ERK1 in Caco-2 associated with member 8
1) Confidence 0.08 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.10
Apparently, activation of ERK1/2 by EGF stimulation was independent of increased RAS-GTP levels.
EGF Positive_regulation (activation) of ERK1
2) Confidence 0.04 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.87 Pain Relevance 0

General Comments

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