INT156836

Context Info Confidence 0.14 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.10

nucleus (ETS1, MAPK7) cell differentiation (MAPK7) nucleoplasm (MAPK7) DNA binding (ETS1) cytoplasm (MAPK7) cytosol (MAPK7)

Anatomy Link Frequency Caco-2 2 ETS1 (Homo sapiens) MAPK7 (Homo sapiens)

Pain Link Frequency Relevance Heat member 8 1 98.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

ERK5-mediated phosphorylation of the transcription factor Ets-1 enhanced 1,25(OH)(2)D(3)-mediated CYP24 gene transcription in proliferating but not differentiated Caco-2 cells due to reduced levels of ERK5 and Ets-1 (total and phosphoprotein levels) in differentiated cells.

Ets-1 Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of ERK5 in Caco-2

1) Confidence 0.14 Published 2009 Journal J. Cell. Physiol. Section Abstract Doc Link 19097033 Disease Relevance 0 Pain Relevance 0.10

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