INT156876

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 10.25
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
sciatic nerve 2
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 620 100.00 Very High Very High Very High
cytokine 344 100.00 Very High Very High Very High
Hyperalgesia 1 99.00 Very High Very High Very High
allodynia 4 98.32 Very High Very High Very High
Sciatic nerve 3 95.88 Very High Very High Very High
peripheral neuropathy 2 92.76 High High
Neuropathic pain 4 87.64 High High
Arthritis 17 84.08 Quite High
Inflammatory response 55 72.76 Quite High
Multiple sclerosis 28 65.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 736 100.00 Very High Very High Very High
Targeted Disruption 40 100.00 Very High Very High Very High
Sepsis 10 100.00 Very High Very High Very High
Disease 325 99.80 Very High Very High Very High
Necrosis 43 99.20 Very High Very High Very High
Hyperalgesia 4 99.00 Very High Very High Very High
Cancer 95 98.84 Very High Very High Very High
Neuropathic Pain 10 98.32 Very High Very High Very High
Urological Neuroanatomy 11 98.12 Very High Very High Very High
Neurodegenerative Disease 40 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, it was suggested that caspase-1 also metabolises another inflammatory mediator, IL-33; however, contrary to IL-1?
Positive_regulation (mediator) of Gene_expression (metabolises) of caspase-1 associated with inflammation
1) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.35 Pain Relevance 0.25
RT-PCR analysis showed increased expression of caspase-1, caspase-12 and caspase-8 genes in the orbito-frontal cortex 14 days after spared nerve injury of the sciatic nerve.
Positive_regulation (increased) of Gene_expression (expression) of caspase-1 in sciatic nerve associated with nervous system injury, urological neuroanatomy and sciatic nerve
2) Confidence 0.27 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.58 Pain Relevance 0.70
The cysteine protease, interleukin-converting enzyme (caspase-1), cleaves the 31–33 kDa precursor, proIL-1, to form the mature and biologically active IL-1?
Positive_regulation (cleaves) of Gene_expression (cysteine protease) of caspase-1
3) Confidence 0.12 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.09 Pain Relevance 0.21
The cysteine protease, interleukin-converting enzyme (caspase-1), cleaves the 31–33 kDa precursor, proIL-1, to form the mature and biologically active IL-1?
Positive_regulation (cleaves) of Gene_expression (cysteine protease) of interleukin-converting enzyme
4) Confidence 0.12 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.09 Pain Relevance 0.21
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (using) of Gene_expression (producing) of ICE associated with targeted disruption
5) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.81 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (-) of Gene_expression (producing) of ICE associated with targeted disruption
6) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.78 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (activation) of Gene_expression (producing) of ICE associated with targeted disruption
7) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.79 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (using) of Gene_expression (producing) of ICE associated with targeted disruption
8) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.81 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (activation) of Gene_expression (producing) of ICE associated with targeted disruption
9) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.79 Pain Relevance 0.13
This was latterly confirmed in pharmacological [32] studies and those using P2X7R knockout mice [33,34], with the activation of the P2X7R by ATP producing a fall in cytoplasmic K+ concentration which in turn stimulates processing of pro-ICE to ICE, and thereby inducing release of mature IL-1?
Positive_regulation (-) of Gene_expression (producing) of ICE associated with targeted disruption
10) Confidence 0.11 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.78 Pain Relevance 0.13
Biglycan null mice have a considerable survival benefit in LPS-induced sepsis due to reduced TLR2 and 4 dependent cytokine synthesis, cellular infiltration into tissues [23], and lower levels of active caspase-1 and mature IL-1?
Positive_regulation (induced) of Gene_expression (levels) of caspase-1 associated with sepsis and cytokine
11) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.39 Pain Relevance 0.43

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