INT156944

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.31
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Setd1a) nucleus (Setd1a)
Anatomy Link Frequency
Notch 1
neural 1
Setd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 1 94.64 High High
Serotonin 1 86.84 High High
antidepressant 3 85.48 High High
fluoxetine 1 80.32 Quite High
Nerve growth factor 1 62.08 Quite High
Hippocampus 2 60.64 Quite High
Peripheral nervous system 1 57.68 Quite High
cytokine 2 51.96 Quite High
Inflammation 2 38.68 Quite Low
Peripheral nerve injury 4 25.36 Quite Low
Disease Link Frequency Relevance Heat
Disease 3 98.08 Very High Very High Very High
Neurological Disease 3 96.72 Very High Very High Very High
Frailty 2 94.92 High High
Manic Depressive Disorder 1 90.56 High High
Vibrio Infection 23 87.92 High High
Malignant Neoplastic Disease 1 79.60 Quite High
Brain Tumor 1 78.80 Quite High
Stress 7 77.56 Quite High
Affective Disorder 2 75.00 Quite High
Nervous System Injury 8 58.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Neg (not) Positive_regulation (activation) of NSC in Notch
1) Confidence 0.30 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.58 Pain Relevance 0.28
We have previously shown that treatments that increase NSC numbers in vivo also confer neuroprotection and behavioral benefits in models of neurological disease [22], [23], [25].
Positive_regulation (increase) of NSC associated with neurological disease
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.58 Pain Relevance 0
The reactive niche might induce NSC into progenitors and effecter cells of the neural lineage that would enhance regeneration and alleviate degeneration.
Spec (might) Positive_regulation (induce) of NSC in neural
3) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2614414 Disease Relevance 0.15 Pain Relevance 0.13

General Comments

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