INT15695

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.01
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (EIF2AK3) cell (EIF2AK3) response to stress (EIF2AK3)
cytoplasm (EIF2AK3)
Anatomy Link Frequency
reticulum 2
neurons 1
brain 1
EIF2AK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 27 96.56 Very High Very High Very High
Hyperalgesia 2 96.36 Very High Very High Very High
Root ganglion neuron 4 89.68 High High
Inflammation 140 89.48 High High
addiction 1 85.28 High High
Inflammatory mediators 28 80.04 Quite High
Kinase C 4 75.92 Quite High
nMDA receptor 6 75.00 Quite High
antagonist 21 66.56 Quite High
cytokine 8 51.00 Quite High
Disease Link Frequency Relevance Heat
Stress 118 99.36 Very High Very High Very High
Colon Cancer 6 98.88 Very High Very High Very High
Hypoxia 29 98.08 Very High Very High Very High
Apoptosis 54 97.40 Very High Very High Very High
Cancer 56 97.16 Very High Very High Very High
Nociception 10 97.00 Very High Very High Very High
Hyperalgesia 6 96.36 Very High Very High Very High
INFLAMMATION 214 89.48 High High
Ganglion Cysts 4 89.36 High High
Starvation 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unilateral injections of 6-hydroxydopamine (6-OHDA) cause significant bilateral increases in striatal proenkephalin (PEK) mRNA in rat brain.
Positive_regulation (increases) of PEK in brain
1) Confidence 0.67 Published 1991 Journal Brain Res. Bull. Section Abstract Doc Link 1756390 Disease Relevance 0 Pain Relevance 0.11
Mitogen activated protein kinases such as phosphorylated extracellular signal-regulated kinase-1 and -2 (pERK 1/2) have been recently demonstrated to play an important role in somatic nociception and hyperalgesia.
Positive_regulation (activated) of pERK associated with nociception and hyperalgesia
2) Confidence 0.49 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964695 Disease Relevance 0.48 Pain Relevance 0.20
In these cells, the PERK-activated ATF3-CHOP signaling pathway mediated the gene expression of pro-apoptotic NAG-1- and NSAID-induced apoptosis.
Positive_regulation (activated) of PERK associated with cinod and apoptosis
3) Confidence 0.49 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.18 Pain Relevance 0.49
True Blue-labeled pERK 1/2-immunoreactive neurons were likewise increased 6 h post-HCl (204%) and were mainly of small size (20-40 microm) and negative for neurofilament 200 (approximately 76%).
Positive_regulation (increased) of pERK in neurons
4) Confidence 0.45 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964695 Disease Relevance 0.55 Pain Relevance 0.26
Sulindac sulfide, the active sulindac metabolite, was shown to trigger the ISRs via eIF2alpha kinase such as RNA-dependent protein kinase-related endoplasmic reticulum kinase (PERK) and RNA-dependent protein kinase (PKR).
Positive_regulation (trigger) of PERK in reticulum
5) Confidence 0.45 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.26 Pain Relevance 0.46
Sulindac sulfide, the active sulindac metabolite, was shown to trigger the ISRs via eIF2alpha kinase such as RNA-dependent protein kinase-related endoplasmic reticulum kinase (PERK) and RNA-dependent protein kinase (PKR).
Positive_regulation (trigger) of RNA-dependent protein kinase-related endoplasmic reticulum kinase in reticulum
6) Confidence 0.41 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.25 Pain Relevance 0.46
PERK (EIF2AK3, eukaryotic translation initiation factor 2-alpha kinase 3), whose mRNA-level was increased by black cohosh treatment, is a kinase linking hypoxia stress reponse and UPR to eIF2?
Positive_regulation (increased) of EIF2AK3 associated with stress and hypoxia
7) Confidence 0.28 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.91 Pain Relevance 0
However, PERK-induced activation of eIF2?
Positive_regulation (activation) of PERK
8) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.37 Pain Relevance 0.04
Semi-qualitative analysis revealed a 2.4 ± 0.4 fold increase in pERK levels (n = 10) when compared to basal while levels of non-phosphorylated ERK2 remained constant.
Positive_regulation (increase) of pERK
9) Confidence 0.17 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.33 Pain Relevance 0.17
Cells stimulated with an effective isoproterenol concentration (100 nM) showed significant increases in the amount of pERK 5 min after drug addition (Figure 4).
Positive_regulation (increases) of pERK
10) Confidence 0.14 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.41 Pain Relevance 0.23
Semi-quantitave analysis of the immunoblots revealed a 1.9 ± 0.4 and 2.6 ± 0.7 fold increase in pERK levels over basal after H-89 (n = 4) or Rp-cAMPS (n = 3) pretreatment, respectively, which are not significantly different than the fold increase for pERK observed without inhibitor pretreatment (2.6 ± 0.9; n = 4).
Positive_regulation (increase) of pERK
11) Confidence 0.14 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.12 Pain Relevance 0.06
Semi-quantitave analysis of the immunoblots revealed a 1.9 ± 0.4 and 2.6 ± 0.7 fold increase in pERK levels over basal after H-89 (n = 4) or Rp-cAMPS (n = 3) pretreatment, respectively, which are not significantly different than the fold increase for pERK observed without inhibitor pretreatment (2.6 ± 0.9; n = 4).
Positive_regulation (increase) of pERK
12) Confidence 0.13 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.14 Pain Relevance 0.07

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