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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.96
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
articular 2
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 97.14 Very High Very High Very High
Neuropeptide 1 91.72 High High
bradykinin 1 90.04 High High
Adalimumab 57 89.28 High High
Inflammation 21 82.72 Quite High
psoriasis 6 79.52 Quite High
alcohol 1 76.56 Quite High
Pain 2 62.32 Quite High
Inflammatory marker 7 56.20 Quite High
Arthritis 46 50.00 Quite Low
Disease Link Frequency Relevance Heat
Low Back Pain 4 94.40 High High
Bacteremia 4 93.56 High High
Sepsis 75 83.36 Quite High
INFLAMMATION 26 82.72 Quite High
Psoriasis 7 79.52 Quite High
Systemic Inflammatory Response Syndrome 30 79.12 Quite High
Obesity 1 75.20 Quite High
Birth Weight 1 73.20 Quite High
Infection 34 62.96 Quite High
Disease 12 60.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokines exert their biological effects on CRP by signaling through their receptors on hepatic cells and activating different kinases and phosphatases leading to translocation of various transcription factors on CRP gene promoter and production of CRP protein.
Positive_regulation (leading) of Localization (translocation) of CRP associated with cytokine
1) Confidence 0.59 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19803417 Disease Relevance 0.60 Pain Relevance 0.60
For placebo-treated patients, the strongest positive associations with radiographic progression (that is, greatest odds ratio (OR)) were observed for baseline CRP as a dichotomous variable (at CRP thresholds > 0.287 mg/dl, ?
Positive_regulation (variable) of Localization (baseline) of CRP
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.14 Pain Relevance 0.28
Bath ankylosing spondylitis disease activity index (BASDAI), bath ankylosing spondylitis functional index (BASFI), visual analogue scale (VAS) for pain, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Schober test, chest expansion measurements, hip involvement, ocular involvement, articular pain, and presence of syndesmophytes were used to assess the disease severity in patients.
Positive_regulation (ankylosing) of Localization (ankylosing) of CRP in articular
3) Confidence 0.14 Published 2009 Journal Joint Bone Spine Section Body Doc Link 19119044 Disease Relevance 0.09 Pain Relevance 0
Correlations between HMGB1, LBP, IL-6 and CRP in children
Positive_regulation (between) of Localization (Correlations) of CRP
4) Confidence 0.08 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 1.12 Pain Relevance 0

General Comments

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