INT157343

Context Info Confidence 0.30 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.89 Pain Relevance 0.43

plasma membrane (AQP4, HLA-DPB1) endosome (HLA-DPB1) transport (AQP4) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1) transmembrane transport (AQP4)

Anatomy Link Frequency central nervous system 1 AQP4 (Homo sapiens) HLA-DPB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 2 97.68 Multiple sclerosis 3 94.72 Spinal cord 1 89.68 medulla 1 83.96 Neuritis 2 70.08

Disease Link Frequency Relevance Heat Demyelinating Disease 7 96.76 Neuromyelitis Optica 3 78.60 Optic Neuritis 2 70.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders.

aquaporin-4 Binding (Association) of HLA-DPB1 in central nervous system associated with central nervous system and demyelinating disease

1) Confidence 0.30 Published 2009 Journal Tissue Antigens Section Title Doc Link 19140826 Disease Relevance 0.89 Pain Relevance 0.43

General Comments

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