INT157422

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.29
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hcn1) transmembrane transport (Hcn1)
Anatomy Link Frequency
motoneurons 1
Hcn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 3 98.44 Very High Very High Very High
Pain 14 98.00 Very High Very High Very High
Spinal cord 102 97.94 Very High Very High Very High
Neurotransmitter 66 86.36 High High
HCN1 1 79.56 Quite High
interneuron 12 69.88 Quite High
Action potential 6 63.84 Quite High
Glutamate 15 43.12 Quite Low
gABA 54 42.48 Quite Low
Central nervous system 42 14.76 Low Low
Disease Link Frequency Relevance Heat
Injury 1 99.56 Very High Very High Very High
Pain 14 98.00 Very High Very High Very High
Disease 9 5.00 Very Low Very Low Very Low
Tremor 6 5.00 Very Low Very Low Very Low
Spasticity 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Purpura 3 5.00 Very Low Very Low Very Low
Polio 3 5.00 Very Low Very Low Very Low
Poisoning 3 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, HCN channels may represent valid targets for novel analgesic agents.
Gene_expression (channels) of HCN associated with analgesic
1) Confidence 0.51 Published 2009 Journal Comb. Chem. High Throughput Screen. Section Abstract Doc Link 19149492 Disease Relevance 0.29 Pain Relevance 0.33
By the mid 50s it was generally accepted that the inhibitory transmitter substance in the cat spinal cord caused permeability changes in the sub-synaptic membrane of motoneurons, and the resultant ion fluxes produced membrane hyperpolarization (Coombs et al., 1955c).
Gene_expression (produced) of hyperpolarization in motoneurons associated with spinal cord
2) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2889717 Disease Relevance 0 Pain Relevance 0.16
The mechanisms whereby application of increasing concentrations of glycine could virtually abolish some IPSPs were examined in more detail by comparing the amplitude of evoked IPSPs (in the reciprocal pathway) and the hyperpolarization produced by increasing [glycine]o.
Gene_expression (produced) of hyperpolarization
3) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2889717 Disease Relevance 0 Pain Relevance 0
The most relevant findings for GlyRs were: (1) application of glycine always produced a hyperpolarization (?
Gene_expression (produced) of hyperpolarization
4) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2889717 Disease Relevance 0 Pain Relevance 0.10

General Comments

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