INT157540

Context Info Confidence 0.41 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 2.55 Pain Relevance 1.42

intracellular (SP1, YY1) DNA binding (SP1, YY1) nucleus (SP1, YY1) cell differentiation (YY1) cytoplasm (SP1) chromosome organization (YY1)

Anatomy Link Frequency lymphocytes 3 SP1 (Homo sapiens) YY1 (Homo sapiens)

Pain Link Frequency Relevance Heat mu opioid receptor 32 99.02 Morphine 8 89.96 addiction 4 47.20

Disease Link Frequency Relevance Heat Immunodeficiency 12 93.76 Syndrome 4 92.88 Infection 20 91.92 Repression 8 89.12 Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Morphine Dependence 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.

Sp1 Binding (interaction) of YY1

1) Confidence 0.41 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.75 Pain Relevance 0.35

Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.

Sp1 Binding (interaction) of Ying Yang 1 in lymphocytes associated with mu opioid receptor

2) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35

Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.

Sp1 Binding (interaction) of YY1 in lymphocytes associated with mu opioid receptor

3) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35

Previous investigation has suggested that expression of the MOR gene in lymphocytes is triggered by cooperative interaction between transcription factors, specificity protein 1 (Sp1) and Ying Yang 1 (YY1), in the promoter region.

specificity protein 1 Binding (interaction) of Ying Yang 1 in lymphocytes associated with mu opioid receptor

4) Confidence 0.30 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.60 Pain Relevance 0.35

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