INT157580

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Context Info
Confidence 0.77
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 8
Disease Relevance 0.73
Pain Relevance 8.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
neurons 2
colon 2
descending colon 1
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 45 100.00 Very High Very High Very High
tolerance 45 100.00 Very High Very High Very High
Antinociceptive 35 100.00 Very High Very High Very High
nMDA receptor 3 100.00 Very High Very High Very High
opioid receptor 110 99.96 Very High Very High Very High
Spinal cord 6 97.96 Very High Very High Very High
Action potential 3 95.24 Very High Very High Very High
intrathecal 10 95.16 Very High Very High Very High
Analgesic 5 92.48 High High
dorsal root ganglion 3 81.72 Quite High
Disease Link Frequency Relevance Heat
Stress Incontinence 9 93.76 High High
Ganglion Cysts 3 81.72 Quite High
Pain 5 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 3 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that cyclin-dependent kinase 5 (Cdk5), activated in morphine antinociceptive tolerance, directly phosphorylates DOR at Thr-161 in DRG neurons.
Phosphorylation (phosphorylates) of Cdk5 in neurons associated with tolerance, opioid receptor, antinociceptive and morphine
1) Confidence 0.77 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.42
Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.
Phosphorylation (phosphorylation) of Cdk5 associated with tolerance, opioid receptor, antinociceptive and morphine
2) Confidence 0.77 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.39
Cdk5 was found to phosphorylate Thr-161 in the second loop of DOR, but not the corresponding residue in the mu-opioid receptor (MOR).
Phosphorylation (phosphorylate) of Cdk5 associated with opioid receptor
3) Confidence 0.76 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.45
Here, we show that cyclin-dependent kinase 5 (Cdk5), activated in morphine antinociceptive tolerance, directly phosphorylates DOR at Thr-161 in DRG neurons.
Phosphorylation (phosphorylates) of cyclin-dependent kinase 5 in neurons associated with tolerance, opioid receptor, antinociceptive and morphine
4) Confidence 0.76 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.42
Our studies indicated that inhibition of Cdk5 activity or overexpression of a DOR mutant lacking the Cdk5 phosphorylation site displayed relatively low cell surface expression and relatively low abilities to form heterodimers of DOR and MOR; intrathecal delivery of a construct expressing the T161A mutant of DOR attenuated morphine antinociceptive tolerance in rats, suggesting that Thr-161 phosphorylation of DOR contributed to Cdk5-mediated morphine antinociceptive tolerance.
Neg (lacking) Phosphorylation (phosphorylation) of Cdk5 associated with tolerance, opioid receptor, antinociceptive, morphine and intrathecal
5) Confidence 0.76 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.86
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Phosphorylation (phosphorylated) of Cdk5 in descending colon associated with action potential and spinal cord
6) Confidence 0.59 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46
We investigated the participation of cyclin-dependent kinase-5 (Cdk5)-mediated N-methyl-D-aspartate receptor (NMDAR) NR2B subunit phosphorylation in cross-organ reflex sensitization caused by colon irritation.
Phosphorylation (phosphorylation) of Cdk5 in colon associated with nmda receptor
7) Confidence 0.59 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.25 Pain Relevance 0.16
We investigated the participation of cyclin-dependent kinase-5 (Cdk5)-mediated N-methyl-D-aspartate receptor (NMDAR) NR2B subunit phosphorylation in cross-organ reflex sensitization caused by colon irritation.
Phosphorylation (phosphorylation) of cyclin-dependent kinase-5 in colon associated with nmda receptor
8) Confidence 0.59 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.25 Pain Relevance 0.16

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