INT157603

Context Info Confidence 0.16 First Reported 2006 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.91 Pain Relevance 0.21

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13) Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)

Anatomy Link Frequency articular cartilage 2 Mmp13 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 6 83.28 Osteoarthritis 23 73.20 agonist 10 68.96 Tendonitis 1 67.76 Inflammation 48 58.32 cytokine 37 36.76 Arthritis 4 5.00 Pain 3 5.00 chemokine 3 5.00 cINOD 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 38 99.02 Stress 4 90.80 Anastomotic Leak 4 82.28 Osteoarthritis 23 73.20 Injury 15 64.88 Wound Healing 11 64.40 INFLAMMATION 53 58.32 Arthritis 11 5.00 Necrosis 2 5.00 Inflammatory Bowel Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BMA resulted in decreased COMP and increased MMP-3 and MMP-13 gene expression.

Positive_regulation (increased) of Gene_expression (expression) of MMP-13

1) Confidence 0.16 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11

Curiously, MMP-13 (also termed collagenase-3) – a protease specific for type II collagen, a primary ECM component of articular cartilage – was among the few genes whose expression was strongly stimulated (in this case approximately eightfold) by glucosamine.

Positive_regulation (stimulated) of Gene_expression (expression) of MMP-13 in articular cartilage

2) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.07 Pain Relevance 0.04

The GLP-2 ligands showed no effects on mRNA levels for the TIMPs, except for an increase under hypoxic conditions with GLP-2 MMB (data not shown), and MMP-13 expression was not changed but trended downward (Figure 6).

Neg (not) Positive_regulation (changed) of Gene_expression (expression) of MMP-13 associated with hypoxia

3) Confidence 0.08 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.84 Pain Relevance 0.06

General Comments

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