INT15771

Context Info Confidence 0.67 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 34 Total Number 38 Disease Relevance 3.16 Pain Relevance 4.11

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1) plasma membrane (Nrg1) cytoplasm (Nrg1)

Anatomy Link Frequency peripheral nerves 3 radial 2 Schwann cells 2 dorsal root ganglia 1 synapses 1 Nrg1 (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 3 100.00 conotoxin 2 99.68 Chronic pancreatitis 4 98.96 Pain 3 98.80 Central nervous system 36 97.60 Delta opioid receptors 3 96.48 Peripheral nervous system 36 93.68 Neurotransmitter 72 91.88 Demyelination 16 91.00 anesthesia 7 90.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 18 99.58 Pancreatitis 4 98.96 Pain 3 98.80 Diabetes Mellitus 41 93.36 Schizophrenia 95 92.68 Liver Disease 1 92.52 Demyelinating Disease 17 91.00 Death 36 84.48 Lifespan 18 81.44 Targeted Disruption 104 78.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When NRG1 is presented to Schwann cells in the context of cell-cell contact, type III but not type I NRG1 regulates P0 gene expression.

Gene_expression (presented) of NRG1 in Schwann cells

1) Confidence 0.67 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16554459 Disease Relevance 0.15 Pain Relevance 0.12

Increasing evidence from genetic linkage studies has identified both the NRG1 (Stefansson et al., 2002; Harrison and Law, 2006) and the ?

Gene_expression (identified) of NRG1

2) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.31 Pain Relevance 0.19

m axonal length; and Nrg1-ECD, 13.20 ± 2.72 clusters/100-?

Gene_expression (length) of Nrg1

3) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

We also demonstrate that Type III Nrg1 back signaling activates a phosphatidylinositol 3-kinase signaling pathway and that activation of this pathway is required for the insertion of preexisting ?

Gene_expression (signaling) of Nrg1

4) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04

Additionally, it has been shown that Type III Nrg1 also functions as a receptor, in that Type III Nrg1–ErbB interaction results in signaling within the Type III Nrg1–expressing cell (Bao et al., 2003, 2004).

Gene_expression (expressing) of Nrg1

5) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.11 Pain Relevance 0.04

Because we do not see effects of Type III Nrg1 back signaling on ?

Gene_expression (effects) of Nrg1

6) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15

Stimulation of Type III Nrg1 back signaling increases surface expression of ?

Gene_expression (back) of Nrg1

7) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

Activation of presynaptic Type III Nrg1 signaling, either by postsynaptic ErbB4 (as shown in Fig.

Gene_expression (presynaptic) of Nrg1

8) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.03

Prior work has shown that presynaptic Type III Nrg1 is critical for establishing stable interactions with postsynaptic partners and, ultimately, for the survival of neuromuscular synapses as well as for glia development and myelination (Wolpowitz et al., 2000; Michailov et al., 2004; Taveggia et al., 2005; Chen et al., 2006).

Gene_expression (presynaptic) of Nrg1 in synapses

9) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

Acute stimulation of Type III Nrg1 back signaling increases the number of ?

Gene_expression (back) of Nrg1

10) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04

Stimulation of Type III Nrg1 back signaling induces an increase in axonal surface ?

Gene_expression (back) of Nrg1

11) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05

Presynaptic Type III Neuregulin1-ErbB signaling targets ?

Gene_expression (Presynaptic) of Neuregulin1

12) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04

Because we do not see effects of Type III Nrg1 back signaling on ?

Gene_expression (signaling) of Nrg1

13) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15

As a result, Type III Nrg1 back signaling, by regulating presynaptic ?

Gene_expression (back) of Nrg1

14) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05

Presynaptic Type III Neuregulin1-ErbB signaling targets ?

Gene_expression (targets) of Neuregulin1

15) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04

7* nAChR levels; Type III Nrg1 functioning as a receptor can regulate insertion of preformed ?

Gene_expression (levels) of Nrg1

16) Confidence 0.67 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

It is worth noting that these risk alleles at the NRG1 locus also have been associated with increased expression of Type I and IV Nrg1 (Law et al., 2006).

Gene_expression (expression) of Nrg1

17) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.32 Pain Relevance 0.04

Reduction of Type III Nrg1 expression results in decreased axonal ?

Gene_expression (expression) of Nrg1

18) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.03

Subsets of primary sensory neurons within the dorsal root ganglia (DRG) express Type III Nrg1 and ?

Gene_expression (express) of Nrg1 in dorsal root ganglia

19) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0

Similarly, KU-32 also prevented the NRG1-induced decrease in the expression of the compact myelin protein zero, P0 (Figure 2C).

Gene_expression (expression) of NRG1

20) Confidence 0.46 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

This test has worked.