INT15772

Context Info Confidence 0.41 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 17 Total Number 22 Disease Relevance 15.77 Pain Relevance 1.45

Anatomy Link Frequency plasma 4 heart 1 Hdlcl1 (Mus musculus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 4 99.92 Arthritis 3 99.10 Paracetamol 8 97.60 Pain 4 96.40 abdominal pain 1 89.08 Angina 7 87.60 Glutamate 1 79.20 Analgesic 2 73.72 Inflammation 10 73.28 cINOD 1 70.48

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 440 100.00 Pancreatitis 4 99.92 Coronary Artery Disease 180 99.84 Disease 42 99.70 Metabolic Syndrome 26 99.68 Arthritis 4 99.10 Diabetes Mellitus 78 98.56 Coronary Heart Disease 18 98.44 Nicotine Addiction 12 97.16 Pain 3 96.40

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

She had extremely low levels of cholesterol and triacylglycerol in her serum, slightly decreased serum phospholipids and normal HDL-cholesterol levels.

Negative_regulation (decreased) of HDL-cholesterol associated with disorder of lipid metabolism

1) Confidence 0.41 Published 1991 Journal J. Hepatol. Section Abstract Doc Link 1918873 Disease Relevance 0.96 Pain Relevance 0.09

A pooled analysis of Framingham and three other major North American trials (the Lipid Research Clinics Prevalence Mortality Follow-up Study, the Coronary Primary Prevention Trial and the Multiple Risk Factor Intervention Trial) showed that for each decrease in HDL-cholesterol of 0.03 mmol/L (1 mg/dL), the risk of coronary heart disease increased by 2% in men and by 3% in women (Gordon et al 1989).

Negative_regulation (decrease) of HDL-cholesterol in heart associated with coronary heart disease and disorder of lipid metabolism

2) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.05 Pain Relevance 0

As the arthritis progressed, the serum total cholesterol and HDL-cholesterol levels were rapidly reversed, finally reaching a level significantly higher than normal, together with rises in the serum free-cholesterol and lipid peroxide levels.

Negative_regulation (reversed) of HDL-cholesterol associated with disorder of lipid metabolism and arthritis

3) Confidence 0.20 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2779005 Disease Relevance 0.82 Pain Relevance 0.22

Since several beta-blocking agents increase the atherogenic VLDL-triglycerides and decrease the atheroprotective HDL-cholesterol we studied if verapamil also affects these lipoproteins or the most atherogenic LDL-cholesterol.

Negative_regulation (decrease) of HDL-cholesterol associated with disorder of lipid metabolism

4) Confidence 0.06 Published 1984 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 6587755 Disease Relevance 0.43 Pain Relevance 0.16

An increase in plasma triglyceride level is frequently associated with concomitant decrease in HDL-cholesterol in the insulin resistance syndrome, and can represent a marker of metabolic alterations (Guida et al 2001).

Negative_regulation (decrease) of HDL-cholesterol in plasma associated with metabolic syndrome and disorder of lipid metabolism

5) Confidence 0.05 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994018 Disease Relevance 1.02 Pain Relevance 0

Under in vivo experiment, BS extract significantly reduced serum total cholesterol (38-48 %), increased serum high-density lipoprotein- cholesterol (HDL-cholesterol, 22-30%).

Negative_regulation (reduced) of HDL-cholesterol associated with disorder of lipid metabolism

6) Confidence 0.04 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15991575 Disease Relevance 0.35 Pain Relevance 0.15

Lovastatin significantly (p < 0.01) lowered LDL-cholesterol (16.8%), total cholesterol (14.0%) and the ratio (p < 0.05) of LDL-cholesterol to HDL-cholesterol (14.9%).

Negative_regulation (lowered) of HDL-cholesterol associated with disorder of lipid metabolism

7) Confidence 0.04 Published 1999 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 10939029 Disease Relevance 0.99 Pain Relevance 0

Policosanol significantly reduced total cholesterol (p < 0.0001) (15.8%), low-density lipoprotein (LDL)-cholesterol (21%) and the ratios of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol (15.8%) and cholesterol to HDL-cholesterol (11.5%).

Negative_regulation (reduced) of HDL-cholesterol associated with disorder of lipid metabolism

8) Confidence 0.02 Published 1999 Journal Int J Tissue React Section Abstract Doc Link 10645516 Disease Relevance 0.55 Pain Relevance 0

Moderate exercise-training has been reported to increase HDL-cholesterol [4,44], but in this study, coffee intake decreased HDL-cholesterol in trained rats.

Negative_regulation (decreased) of HDL-cholesterol associated with disorder of lipid metabolism

9) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.61 Pain Relevance 0

Coffee intake can promote activity of antioxidant enzymes with increasing MDA level and decreasing HDL-cholesterol in physically trained rats This study investigated the effect of coffee intake and exercise on the antioxidative activity and plasma cholesterol profile of physically trained rats while they were exercising.

Negative_regulation (decreasing) of HDL-cholesterol in plasma associated with disorder of lipid metabolism

10) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Title Doc Link PMC2933445 Disease Relevance 0.27 Pain Relevance 0

This study showed that freeze dried instant coffee consumption induced a favorable turn on of the activities of antioxidant enzymes but also increased MDA and decreased HDL-cholesterol in physically trained rats.

Negative_regulation (decreased) of HDL-cholesterol associated with disorder of lipid metabolism

11) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.33 Pain Relevance 0

Therefore, coffee intake can promote activities of antioxidant enzyme but it also increases MDA and decreases HDL-cholesterol in physically trained rats.

Negative_regulation (decreases) of HDL-cholesterol associated with disorder of lipid metabolism

12) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2933445 Disease Relevance 0.38 Pain Relevance 0

Therefore, despite the many uncertainties regarding the mode of action, these results suggest that coffee intake can promote activities of antioxidant enzyme but also increase MDA and decrease HDL-cholesterol in physically trained rats.

Negative_regulation (decrease) of HDL-cholesterol associated with disorder of lipid metabolism

13) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.63 Pain Relevance 0

By all accounts, this study observed coffee intake induced significant increase in MDA levels and significant decrease in HDL-cholesterol, and other studies reported that coffee intake increased tHcy.

Negative_regulation (decrease) of HDL-cholesterol associated with disorder of lipid metabolism

14) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.80 Pain Relevance 0

The levels of tissue total lipids and serum LDL-cholesterol were also elevated with depleted levels of serum HDL-cholesterol and tissue phospholipid.

Negative_regulation (depleted) of HDL-cholesterol associated with disorder of lipid metabolism

15) Confidence 0.01 Published 2005 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16132689 Disease Relevance 0.43 Pain Relevance 0.41

HDL-cholesterol and apo A-I levels in CP-I and CP-II groups significantly decreased compared to those in sex- and age-matched healthy controls (p less than 0.05), whereas there were not significant differences in triglyceride and total cholesterol levels between these groups and controls.

Negative_regulation (decreased) of HDL-cholesterol associated with disorder of lipid metabolism

16) Confidence 0.01 Published 1991 Journal Rinsho Byori Section Abstract Doc Link 1762196 Disease Relevance 0.87 Pain Relevance 0.33

Serum levels of cholesterol, HDL-cholesterol, triglycerides, lipoprotein Lp(a), and the fibrinolysis factors tPA (tissue plasminogen activator) and PAI-1 activity (plasminogen activator inhibitor) were compared with sensory thresholds for vibration, electrical current perception, and pain in a population-based study comprising 239 patients with diabetes mellitus Type 1, aged 15-50 years.

Negative_regulation (inhibitor) of HDL-cholesterol associated with pain, diabetes mellitus and disorder of lipid metabolism

17) Confidence 0.01 Published 1995 Journal Diabet. Med. Section Abstract Doc Link 7554780 Disease Relevance 0.58 Pain Relevance 0.10

It is already known that non-insulin-dependent diabetes mellitus is often associated with increased triglyceride, LDL-cholesterol and a reduced HDL-cholesterol levels [26,27].

Negative_regulation (reduced) of HDL-cholesterol associated with diabetes mellitus and disorder of lipid metabolism

18) Confidence 0.01 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2365944 Disease Relevance 1.70 Pain Relevance 0

Also this variant was associated with reduced HDL-cholesterol levels in our population.

Negative_regulation (reduced) of HDL-cholesterol associated with disorder of lipid metabolism

19) Confidence 0.01 Published 2003 Journal BMC Med Genet Section Body Doc Link PMC201027 Disease Relevance 0.82 Pain Relevance 0

HDL-cholesterol levels were significantly lower in CAD subjects, but the total plasma cholesterol did not differ between the groups.

Negative_regulation (lower) of HDL-cholesterol in plasma associated with coronary artery disease and disorder of lipid metabolism

20) Confidence 0.01 Published 2003 Journal BMC Med Genet Section Body Doc Link PMC201027 Disease Relevance 0.91 Pain Relevance 0

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