INT157805

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 12.85
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
fibroblasts 6
lung 6
capsule 2
anterior chamber 2
mesenchymal cells 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 467 99.80 Very High Very High Very High
Inflammation 310 99.34 Very High Very High Very High
Arthritis 88 98.56 Very High Very High Very High
metalloproteinase 60 98.24 Very High Very High Very High
agonist 9 98.00 Very High Very High Very High
Chronic pancreatitis 1 95.76 Very High Very High Very High
Inflammatory response 45 94.52 High High
imagery 9 93.44 High High
cytokine 125 91.48 High High
chemokine 36 90.52 High High
Disease Link Frequency Relevance Heat
Injury 89 99.86 Very High Very High Very High
Fibrosis 398 99.80 Very High Very High Very High
Targeted Disruption 104 99.72 Very High Very High Very High
Contracture 5 99.44 Very High Very High Very High
Osteogenesis Imperfecta 112 99.36 Very High Very High Very High
INFLAMMATION 349 99.34 Very High Very High Very High
Arthritis 85 98.56 Very High Very High Very High
Congenital Anomalies 26 98.32 Very High Very High Very High
Wound Healing 7 96.48 Very High Very High Very High
Pancreatitis 2 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Determination of collagen orientation
Negative_regulation (Determination) of Gene_expression (orientation) of collagen
1) Confidence 0.34 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2927597 Disease Relevance 0 Pain Relevance 0.05
Ulrich et al35 found that the balance between MMPs and TIMPs is disturbed in patients with capsule contracture thus causing alteration in synthesis and deposition of collagen surrounding implants.36
Negative_regulation (deposition) of Gene_expression (synthesis) of collagen in capsule associated with metalloproteinase and contracture
2) Confidence 0.24 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.70 Pain Relevance 0.42
CONCLUSIONS: This study indicates that borneol has anti-fibrosis activity and the mechanism may partly be relevant to its inhibiting effects on fibroblasts mitosis, collagen and TIMP-1 production.
Negative_regulation (inhibiting) of Gene_expression (production) of collagen in fibroblasts
3) Confidence 0.24 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Borneol, from 18.75 to 300 microg/ml, could significantly (P < 0.05) decrease the growth of fibroblasts and very significantly (P < 0.01) inhibit collagen production in a concentration dependant manner.
Negative_regulation (inhibit) of Gene_expression (production) of collagen in fibroblasts
4) Confidence 0.24 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.07 Pain Relevance 0
Pertinent to the regulation of collagen in the prostate, androgen deprivation induces marked morphological changes in rat prostatic smooth muscle cells [62], [63] reduces collagen synthesis, and induces a collagen fibrillar reorganization in the rat ventral prostate [64], [65], [66].
Negative_regulation (reduces) of Gene_expression (synthesis) of collagen in ventral
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.72 Pain Relevance 0.11
We evaluated the efficacy of halofuginone, an inhibitor of collagen synthesis and myofibroblast activation, in preventing cerulein-induced pancreas fibrosis.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of collagen in pancreas associated with fibrosis
6) Confidence 0.12 Published 2009 Journal Pancreas Section Abstract Doc Link 19188864 Disease Relevance 0.46 Pain Relevance 0.28
As a preliminary experiment in the in vivo studies, the fibroblasts cultured from a transgenic fibrotic model were used to assess the possibility and potential mechanisms of SPARC siRNA in attenuating the collagen expression in vitro.
Negative_regulation (attenuating) of Gene_expression (expression) of collagen in fibroblasts associated with fibrosis and targeted disruption
7) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 1.72 Pain Relevance 0.16
Cathepsin K transgenic mice exhibit decreased collagen deposition in their lungs in response to bleomycin compared to wild-type mice
Negative_regulation (decreased) of Gene_expression (deposition) of collagen in lungs associated with targeted disruption
8) Confidence 0.09 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.24 Pain Relevance 0
Determination of collagen content
Negative_regulation (Determination) of Gene_expression (content) of collagen
9) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0 Pain Relevance 0
We used Ctgf siRNA as a positive control for inhibition of Ctgf and collagen expression.
Negative_regulation (inhibition) of Gene_expression (expression) of collagen
10) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
For instance, it was repetitively shown that elevation of cAMP level results in inhibition of lung fibroblast proliferation, migration, transition to myofibroblasts and collagen production [11-13].
Negative_regulation (inhibition) of Gene_expression (production) of collagen in lung
11) Confidence 0.07 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.76 Pain Relevance 0.31
Additionally, it has been observed a decreased collagen deposition in the wounds of these animals.
Negative_regulation (decreased) of Gene_expression (deposition) of collagen associated with injury
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 1.19 Pain Relevance 0.54
A collateral effect of this delayed clearance of inflammation in a model of skin wounds was a decreased collagen deposition and therefore a delayed healing [10].
Negative_regulation (decreased) of Gene_expression (deposition) of collagen in skin associated with inflammation and injury
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 1.11 Pain Relevance 0.62
In severe and moderately severe OI (generally due to a structural defect of type I collagen synthesis) agents increasing the production of type I collagen, such as GH, do not represent a suitable treatment, other agents that reduce bone resorption, such as BPs, are preferable for their action in increasing BMC.
Negative_regulation (defect) of Gene_expression (synthesis) of collagen associated with osteogenesis imperfecta and hypercalcemia
14) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940745 Disease Relevance 0.72 Pain Relevance 0
Marimastat does not diminish net collagen deposition and fibrosis formation
Neg (not) Negative_regulation (diminish) of Gene_expression (deposition) of collagen associated with fibrosis
15) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.72 Pain Relevance 0.18
Some ocular abnormalities have been described in the knockout mouse model [19] such as an abnormal keratocan expression in the cornea, abnormal collagen fibrillogenesis, and a reduction in the depth of the anterior chamber.
Negative_regulation (reduction) of Gene_expression (expression) of collagen in anterior chamber associated with targeted disruption and congenital anomalies
16) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 1.52 Pain Relevance 0
-stimulated reductions in collagen synthesis.
Negative_regulation (reductions) of Gene_expression (synthesis) of collagen
17) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945020 Disease Relevance 0 Pain Relevance 0
Treatment with both H4R, 20 mg/kg, and anti-IL-13 reduced free collagen levels (vehicle, 55.83 ± 2.4 ?
Negative_regulation (reduced) of Gene_expression (levels) of collagen
18) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.83 Pain Relevance 0.17
In CIA mice treated by B7-H4VC plasmid, the depletion of Gr-1+ cells completely inhibited the production of sH4-mediated increases of autoantibodies and T cell proliferation to collagen.


Negative_regulation (inhibited) of Gene_expression (production) of collagen in T cell associated with arthritis
19) Confidence 0.03 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.85 Pain Relevance 0.47
Measurement of collagen content of the lung
Negative_regulation (Measurement) of Gene_expression (content) of collagen in lung
20) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.07 Pain Relevance 0

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