INT157832

Context Info Confidence 0.77 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.04 Pain Relevance 0.08

aging (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2) transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)

Anatomy Link Frequency urine 3 inner medulla 1 Aqp2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 3 54.40 anesthesia 10 10.00 isoflurane 12 5.00 antagonist 9 5.00 fibrosis 3 5.00 bradykinin 3 5.00

Disease Link Frequency Relevance Heat Chronic Renal Failure 372 81.48 Uremia 12 36.44 Congenital Anomalies 3 28.72 Hypertrophy 33 5.00 Natriuresis 7 5.00 Fibrosis 3 5.00 Disorders Of Creatine Metabolism 3 5.00 Hypercalcemia 3 5.00 Injury 3 5.00 Bartter Syndrome 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, in a parallel study, we found that treatment with the AT1 receptor blocker candesartan in NaCl-restricted normal rats prevented the increase of the expression of inner medullary AQP2 and phosphorylated-AQP2 (AQP2 phosphorylated in the PKA-phosphorylation consensus site Ser-256) and the increase of urine concentration in response to the long-term dDAVP treatment (25).

Phosphorylation (phosphorylated) of AQP2 in urine

1) Confidence 0.77 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.68 Pain Relevance 0.03

Interestingly, in a parallel study, we found that treatment with the AT1 receptor blocker candesartan in NaCl-restricted normal rats prevented the increase of the expression of inner medullary AQP2 and phosphorylated-AQP2 (AQP2 phosphorylated in the PKA-phosphorylation consensus site Ser-256) and the increase of urine concentration in response to the long-term dDAVP treatment (25).

Phosphorylation (phosphorylated) of AQP2 in urine

2) Confidence 0.66 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.68 Pain Relevance 0.03

RESULTS: Polyuria and increased natriuresis were seen 6 h after LPS injection alongside downregulation of both AQP2 and S256-phosphorylated AQP2 in CTX/OSOM and ISOM but not in inner medulla (IM).

Phosphorylation (phosphorylated) of AQP2 in inner medulla

3) Confidence 0.61 Published 2009 Journal Nephrol. Dial. Transplant. Section Body Doc Link 19193739 Disease Relevance 0 Pain Relevance 0

Interestingly, in a parallel study, we found that treatment with the AT1 receptor blocker candesartan in NaCl-restricted normal rats prevented the increase of the expression of inner medullary AQP2 and phosphorylated-AQP2 (AQP2 phosphorylated in the PKA-phosphorylation consensus site Ser-256) and the increase of urine concentration in response to the long-term dDAVP treatment (25).

Phosphorylation (phosphorylated) of AQP2 in urine

4) Confidence 0.59 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

This test has worked.