INT158025

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.03
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 2
lymph node 1
CII 1
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 54 98.76 Very High Very High Very High
Arthritis 38 90.56 High High
cytokine 16 84.92 Quite High
Inflammation 15 63.60 Quite High
COX-2 inhibitor 2 50.00 Quite Low
cINOD 2 50.00 Quite Low
tolerance 9 33.48 Quite Low
fibrosis 3 14.64 Low Low
rheumatoid arthritis 25 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 40 100.00 Very High Very High Very High
Immunization 5 99.64 Very High Very High Very High
Adenocarcinoma 93 99.32 Very High Very High Very High
Pancreatitis 54 98.76 Very High Very High Very High
Pancreatic Cancer 87 98.60 Very High Very High Very High
Metastasis 15 97.80 Very High Very High Very High
Cancer 47 96.64 Very High Very High Very High
Hypercalcemia 14 92.36 High High
Arthritis 65 90.56 High High
Osteogenic Sarcomas 9 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects on alkaline phosphatase (ALP) activity and osteocalcin were not clearly demonstrated.
Regulation (Effects) of osteocalcin
1) Confidence 0.60 Published 2008 Journal Int J Oral Maxillofac Implants Section Body Doc Link 19216276 Disease Relevance 0 Pain Relevance 0
Correlation analysis of BGLAP mRNA and serum levels with clinico-pathological parameters of PDAC patients revealed no significant difference in the median BGLAP mRNA or serum levels in PDAC patients with lymph node metastasis compared to PDAC patients without lymph node metastasis (p = 0.9; data not shown).
Neg (no) Regulation (difference) of BGLAP in lymph node associated with adenocarcinoma and metastasis
2) Confidence 0.43 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.30 Pain Relevance 0.24
Immunization with CII did not affect the levels of osteocalcin.
Neg (not) Regulation (affect) of osteocalcin in CII associated with immunization
3) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.22 Pain Relevance 0.38
In line with this argument, down-regulation of BGLAP levels using siRNA molecules resulted in a significant reduction in pancreatic cancer cell growth and invasion.
Regulation (regulation) of BGLAP associated with pancreatic cancer
4) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.47 Pain Relevance 0.08
As the cellular composition of bulk PDAC and CP tissues is different than that of normal pancreatic tissues, BGLAP mRNA values were normalized to amylase-2A (Amy2A) mRNA levels for each tissue sample to exclude the mRNA expression of BGLAP in the acini (figure 1B).
Regulation (values) of BGLAP associated with adenocarcinoma and chronic pancreatitis
5) Confidence 0.26 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.82 Pain Relevance 0.41
Osteocalcin acts in this context primarily by regulating insulin expression and secretion.
Regulation (acts) of Osteocalcin
6) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.39 Pain Relevance 0
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown.

Regulation (modulating) of osteocalcin in osteoblast associated with osteoporosis
7) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2606962 Disease Relevance 0.57 Pain Relevance 0
Although osteocalcin bioactivity is regulated by at least two gene products within the osteoblast, Esp and ?
Regulation (regulated) of osteocalcin in osteoblast associated with osteoporosis
8) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.25 Pain Relevance 0

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