INT158270

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Context Info
Confidence 0.57
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.49
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm5) plasma membrane (Trpm5) biological_process (Trpm5)
Anatomy Link Frequency
noses 1
Trpm5 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 74 90.24 High High
imagery 147 86.24 High High
TRP channel 19 69.88 Quite High
fifth nerve 14 40.96 Quite Low
substance P 36 31.44 Quite Low
addiction 12 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 147 99.96 Very High Very High Very High
Taste Disorders 3 66.24 Quite High
Aging 6 54.24 Quite High
Dislocations 6 36.16 Quite Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Brain Injury 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike the TRPM5 inhibitor, U73122 also disrupted the regulation on the access of lilial in both wild type and TRPM5 knockout mice.
Negative_regulation (inhibitor) of TRPM5 associated with targeted disruption
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.56 Pain Relevance 0.04
Application of TRPM5 inhibitor produced similar effect.
Negative_regulation (inhibitor) of TRPM5
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.46 Pain Relevance 0
Genetic knockout and pharmacological inhibition of TRPM5 resulted in larger amounts of bitter compounds entering the VNOs.
Negative_regulation (inhibition) of TRPM5 associated with targeted disruption
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912856 Disease Relevance 0.16 Pain Relevance 0.08
Further, we determined sensory signaling transduction mechanisms using both TRPM5 knockout mice and inhibitors to block the activity of TRPM5 and PLC.
Negative_regulation (block) of TRPM5 associated with targeted disruption
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.10 Pain Relevance 0
In contrast, MgSO(4) and CuSO(4) were aversive to WT mice, but for MgSO(4) the aversion was abolished in TRPM5 knock-out animals, and for CuSO(4), aversion decreased in both TRPV1- and TRPM5-deficient animals.
Negative_regulation (abolished) of TRPM5 associated with targeted disruption
5) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19244541 Disease Relevance 0.26 Pain Relevance 0.12
In contrast, MgSO(4) and CuSO(4) were aversive to WT mice, but for MgSO(4) the aversion was abolished in TRPM5 knock-out animals, and for CuSO(4), aversion decreased in both TRPV1- and TRPM5-deficient animals.
Negative_regulation (decreased) of TRPM5 associated with targeted disruption
6) Confidence 0.42 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19244541 Disease Relevance 0.26 Pain Relevance 0.12
Similar to the TRPM5 inhibitor, application of the PLC inhibitor U73122 also disrupted the regulation on access to the VNO of bitter compounds in wild type but not in TRPM5 knockout mice.
Negative_regulation (inhibitor) of TRPM5 associated with targeted disruption
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.50 Pain Relevance 0.04
TRPM5 inhibitors Ph3PO (100 µM) and PLC inhibitor U73122 (10 µM) respectively were delivered to the noses of individual animals using the same method described in stimulus delivery.
Negative_regulation (inhibitors) of TRPM5 in noses
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0
Distribution of TRPV1-4, TRPM5, TRPM8, and TRPA1 in mouse OE
Negative_regulation (Distribution) of TRPM5
9) Confidence 0.41 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0 Pain Relevance 0
At low concentrations, FeSO(4) and ZnSO(4) were perceived as pleasant stimuli by WT mice, and this effect was fully reversed in TRPM5 knock-out mice.
Negative_regulation (reversed) of TRPM5 associated with targeted disruption
10) Confidence 0.36 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19244541 Disease Relevance 0.19 Pain Relevance 0.12

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