INT158567

Context Info Confidence 0.43 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.20

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf) extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)

Anatomy Link Frequency PSC 2 Ctgf (Mus musculus)

Pain Link Frequency Relevance Heat alcohol 2 80.08 fibrosis 2 68.08 Chronic pancreatitis 1 62.56

Disease Link Frequency Relevance Heat Primary Sclerosing Cholangitis 7 99.28 Stress 1 69.52 Fibrosis 2 68.08 Pancreatitis 1 62.56 Alcoholic Pancreatitis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the presence of 4MP, DAS, or the anti-oxidants vitamin D or catalase, there was a substantial decrease in the ability of ethanol to stimulate CCN2 mRNA expression and a concomitant decrease in CCN2-positive PSC.

Negative_regulation (decrease) of Transcription (expression) of CCN2 in PSC associated with primary sclerosing cholangitis

1) Confidence 0.43 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.73 Pain Relevance 0.20

General Comments

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