INT158674

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm1) nucleoplasm (Calm1) cytoskeleton (Calm1)
cell cycle (Calm1) cellular_component (Calm1) biological_process (Calm1)
Anatomy Link Frequency
striatum 2
Calm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 1 60.24 Quite High
antagonist 1 58.80 Quite High
antidepressant 1 33.84 Quite Low
fluoxetine 1 32.64 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 3 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results indicated that repeated treatment with haloperidol, clozapine or risperidone increased CaM protein and CaMII mRNA levels but decreased calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) IV (CaMKIV), kinase alpha (CaMKKalpha), kinase beta (CaMKKbeta) and calcineurin protein levels in the striatum of Sprague-Dawley rats (Rattus Norvegicus).
Negative_regulation (decreased) of Gene_expression (levels) of CaMII mRNA in striatum
1) Confidence 0.06 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.16 Pain Relevance 0.06

General Comments

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