INT158733

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Plxna3) enzyme binding (Esr1) DNA binding (Esr1)
protein complex (Esr1) cytoplasm (Esr1) signal transduction (Plxna3)
Anatomy Link Frequency
autonomic 1
Esr1 (Rattus norvegicus)
Plxna3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 1 89.84 High High
Endogenous opioid 1 85.96 High High
Pain 1 84.68 Quite High
Opioid 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Menopausal Vasomotor Symptoms 1 100.00 Very High Very High Very High
Anxiety Disorder 1 89.32 High High
Pain 1 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The natural selective estrogen receptor modulator DT56a (Femarelle), derived from soybean, has been shown to relieve menopausal vasomotor symptoms with no effect on sex steroid hormone levels or endometrial thickness.The purpose of the present study was to evaluate the neuroendocrine effect of DT56a administration through the evaluation of brain content of allopregnanolone (AP), an endogenous neurosteroid gamma-aminobutyric acid agonist with anxiolytic properties, and through the assessment of beta-endorphin (beta-END), the endogenous opioid implicated in pain mechanism, emotional state, and autonomic control.
estrogen receptor modulator Neg (no) Regulation (effect) of sex in autonomic associated with pain, anxiety disorder, endogenous opioid, agonist and menopausal vasomotor symptoms
1) Confidence 0.03 Published 2009 Journal Menopause Section Abstract Doc Link 19295450 Disease Relevance 0.27 Pain Relevance 0.29

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