INT158843

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.89
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (NALCN)
Anatomy Link Frequency
radial 1
nerve 1
neuron 1
pore 1
neural 1
NALCN (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 4 99.72 Very High Very High Very High
Stimulus evoked pain 2 98.68 Very High Very High Very High
sSRI 16 97.52 Very High Very High Very High
Pain 180 96.84 Very High Very High Very High
Central nervous system 76 96.70 Very High Very High Very High
Cannabinoid receptor 7 96.64 Very High Very High Very High
Cannabinoid 18 95.28 Very High Very High Very High
spinal dorsal horn 4 90.60 High High
Analgesic 15 89.60 High High
allodynia 16 89.36 High High
Disease Link Frequency Relevance Heat
Nociception 20 99.08 Very High Very High Very High
Pain 239 98.68 Very High Very High Very High
Hypersensitivity 4 98.48 Very High Very High Very High
Confusion 4 91.84 High High
Sleep Disorders 13 91.28 High High
Disease 31 91.00 High High
Cardiovascular Disorder Under Development 2 90.60 High High
Neuropathic Pain 40 89.36 High High
Nervous System Injury 26 88.64 High High
Cognitive Disorder 4 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of transducer ion channels expressed at nociceptive terminals occurs upon activation of metabotropic cannabinoid receptors, but direct cannabinoid action on ion channels involved in sensory transduction or regulation of neuron excitability likely contributes to the peripheral cannabinoid effects.
Regulation (Modulation) of ion in neuron associated with nociception, cannabinoid receptor and cannabinoid
1) Confidence 0.04 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19306092 Disease Relevance 0.50 Pain Relevance 0.79
We chose as molecular targets those ion channels shown not only to be affected by sour stimuli, but also responsive to the sourness of the stimuli rather than only to their pH.
Regulation (affected) of ion
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0.08 Pain Relevance 0.04
The EC50 or IC50 of SSRIs for each target is approximated by the radial distance from the center of the map (based on electrophysiology data for the ion channel targets and on binding data for the metabotropic target receptors).
Regulation (targets) of ion in radial associated with ssri
3) Confidence 0.00 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2838756 Disease Relevance 0 Pain Relevance 0.48
To demonstrate that CNS drugs are generally promiscuous agents and illustrate how mapping promiscuity can guide drug discovery, we collected published examples of acute, direct functional modulation of ligand-gated ion channels (LGICs) by a total of 170 pharmaceutical and endogenous molecules, as demonstrated by in vitro electrophysiology.
Regulation (modulation) of ion associated with central nervous system
4) Confidence 0.00 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2838756 Disease Relevance 0.09 Pain Relevance 0.22
This initiates a variety of effects, including direct neural excitation, activation of a signaling cascade via the phophorylation of NMDA receptors, and altered regulation of the neural chloride-ion transporter that contributes to pain hypersensitivity [157].
Regulation (regulation) of ion in neural associated with nmda receptor, hypersensitivity and stimulus evoked pain
5) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.14 Pain Relevance 1.19
An alternative approach to regulate ion channels is to block the trafficking of channels to the nerve membrane.
Regulation (regulate) of ion in nerve
6) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.01 Pain Relevance 0.86
Pharmacological studies have disclosed that the functions of the voltage-gated ion channel proteins can be classified into three complementary aspects: ion conductance, pore gating and regulation.
Regulation (regulation) of ion in pore
7) Confidence 0.00 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 0.06 Pain Relevance 0.06

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