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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) protein binding transcription factor activity (Smad3)
DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3)
Anatomy Link Frequency
brain 2
Smad3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 2 75.00 Quite High
Inflammation 3 25.00 Low Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Negative_regulation (decreased) of Gene_expression (expression) of Smad3 in brain
1) Confidence 0.42 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.13 Pain Relevance 0.13

General Comments

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