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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 60
Total Number 63
Disease Relevance 41.73
Pain Relevance 7.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 4
hepatocytes 3
platelet 3
body 3
myometrium 1
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 256 99.16 Very High Very High Very High
Angina 54 98.64 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 13 97.24 Very High Very High Very High
fibrosis 183 97.16 Very High Very High Very High
aspirin 125 96.22 Very High Very High Very High
Dismenorea 6 95.60 Very High Very High Very High
cytokine 83 94.92 High High
cva 30 92.92 High High
Pain 17 92.24 High High
Inflammatory response 167 88.12 High High
Disease Link Frequency Relevance Heat
Fibrosis 223 100.00 Very High Very High Very High
Metabolic Syndrome 137 100.00 Very High Very High Very High
Insulin Resistance 73 100.00 Very High Very High Very High
Hyperinsulinism 25 99.90 Very High Very High Very High
Diabetes Mellitus 541 99.84 Very High Very High Very High
Obesity 135 99.84 Very High Very High Very High
Cardiovascular Disease 147 99.80 Very High Very High Very High
Adhesions 35 99.64 Very High Very High Very High
Myocardial Infarction 293 99.48 Very High Very High Very High
Coronary Artery Disease 182 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A randomized controlled clinical trial to evaluate the efficacy, safety, cost-effectiveness and effect on PAI-1 levels of the three low-molecular-weight heparins--enoxaparin, nadroparin and dalteparin.
Gene_expression (levels) of PAI-1
1) Confidence 0.62 Published 2006 Journal Pharmacology Section Title Doc Link 17057417 Disease Relevance 0 Pain Relevance 0.09
The present study was conducted to compare the efficacy, safety, cost-effectiveness and effects on plasminogen activator inhibitor-1 (PAI-1) levels of three LMWHs--enoxaparin, nadroparin and dalteparin.
Gene_expression (levels) of PAI-1
2) Confidence 0.55 Published 2006 Journal Pharmacology Section Abstract Doc Link 17057417 Disease Relevance 0 Pain Relevance 0.09
In contrast, PAI-1 levels in the RA group remained unchanged over time.
Gene_expression (levels) of PAI-1
3) Confidence 0.55 Published 1993 Journal Anesthesiology Section Body Doc Link 8363067 Disease Relevance 0 Pain Relevance 0
PAI-1 levels in the GA group increased from 13.6 +/- 2.1 activity units (AU)/ml to 20.2 +/- 2.6 AU/ml at 24 h and returned to baseline at 72 h.
Gene_expression (levels) of PAI-1
4) Confidence 0.55 Published 1993 Journal Anesthesiology Section Body Doc Link 8363067 Disease Relevance 0 Pain Relevance 0
The results suggest that insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothelial cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease.
Gene_expression (synthesis) of PAI in hepatocytes associated with increased venous pressure under development
5) Confidence 0.54 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2470343 Disease Relevance 0.54 Pain Relevance 0.24
The results suggest that insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothelial cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease.
Gene_expression (synthesis) of PAI in hepatocytes associated with increased venous pressure under development
6) Confidence 0.54 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2470343 Disease Relevance 0.54 Pain Relevance 0.24
Possible risk factors for myocardial infarction include high insulin and PAI-1 levels, which correlate with one another in healthy subjects, and fibrinogen, which together with PAI-1, is an acute-phase reactant.
Gene_expression (levels) of PAI associated with hyperinsulinism and myocardial infarction
7) Confidence 0.54 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2470343 Disease Relevance 0.45 Pain Relevance 0.16
Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been shown to exist in 40 to 60% of patients with stable coronary artery disease and have been suggested to be responsible for the development of coronary thrombotic complications.
Gene_expression (levels) of PAI in coronary artery associated with coronary artery disease
8) Confidence 0.53 Published 1990 Journal Thromb. Haemost. Section Abstract Doc Link 2119522 Disease Relevance 0.78 Pain Relevance 0.39
Recently the production of PAI-1 by adipose tissue, in particular by tissue from omentum, has been demonstrated and could be an important contributor to the elevated plasma PAI-1 levels observed in insulin resistant patients.
Gene_expression (production) of PAI-1 in plasma associated with obesity
9) Confidence 0.52 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.01 Pain Relevance 0.06
Many clinical studies have indicated that the insulin resistance syndrome, which is a situation predisposing to diabetes and ischemic heart disease, may be a major regulator of PAI-1 expression, especially in determining plasma PAI-1 levels.
Gene_expression (expression) of PAI-1 in plasma associated with coronary artery disease, diabetes mellitus and metabolic syndrome
10) Confidence 0.52 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 0.90 Pain Relevance 0
1 protein is involved in expression of human Serpine1 mRNA in smooth muscle cells from myometrium of human females [41].
Gene_expression (expression) of Serpine1 mRNA in myometrium
11) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.69 Pain Relevance 0.16
Furthermore, the levels of circulating PAI-1 were higher 24 hours postoperatively among patients in the GEN group (P < 0.05).
Gene_expression (levels) of PAI-1
12) Confidence 0.46 Published 1995 Journal Am Surg Section Abstract Doc Link 7661476 Disease Relevance 0.07 Pain Relevance 0.28
PAI-1, obesity, insulin resistance and risk of cardiovascular events.
Gene_expression (resistance) of PAI-1 associated with metabolic syndrome and insulin resistance
13) Confidence 0.45 Published 1997 Journal Thromb. Haemost. Section Title Doc Link 9198234 Disease Relevance 1.00 Pain Relevance 0.06
Taken together these results support the notion that PAI-1 can be a link between obesity, insulin resistance and cardiovascular disease.
Gene_expression (resistance) of PAI-1 associated with cardiovascular disease, metabolic syndrome and insulin resistance
14) Confidence 0.45 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 1.22 Pain Relevance 0.09
In the current study, a total of 19 parameters must be estimated in the maximum conditional logistic regression model under consideration, which considers all possible main effects and two-way interactions among three polymorphisms with three genotypes each (1 for the intercept, 2 each for the main effects of ACE, PAI-1, and t-PA, and 4 each for the ACE × PAI-1, ACE × t-PA, and PAI-1 × t-PA interactions).
Gene_expression (effects) of PAI-1
15) Confidence 0.28 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.14 Pain Relevance 0.03
Increased plasminogen activator inhibitor antigen levels in diabetic patients with stable angina.
Gene_expression (levels) of plasminogen activator inhibitor associated with angina and diabetes mellitus
16) Confidence 0.26 Published 1991 Journal Blood Coagul. Fibrinolysis Section Title Doc Link 1772997 Disease Relevance 2.19 Pain Relevance 0.40
The magnitude of the risk was substantial (1.5-fold increase in risk for those with the combined ACE DD genotype and at least one PAI-1 4G allele) and comparable to that of other risk factors for which interventions are undertaken.
Gene_expression (allele) of PAI-1 4G
17) Confidence 0.24 Published 2004 Journal BMC Bioinformatics Section Body Doc Link PMC419697 Disease Relevance 0.09 Pain Relevance 0
Although E2 alone did not affect PAI-1 output, MPA and E2+MPA significantly enhanced PAI-1 production (2.5 +/- 0.7 vs 8.2 +/- 2.0 ng/mL per microg protein for E2+MPA [3.3-fold]; P < .01).
Gene_expression (production) of PAI-1
18) Confidence 0.22 Published 2007 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 17403427 Disease Relevance 0 Pain Relevance 0
Corresponding effects on PAI-1 mRNA levels were elicited by MPA and thrombin as seen for PAI-1 protein expression, suggesting that these up-regulatory effects are transcriptionally mediated.
Gene_expression (expression) of PAI-1
19) Confidence 0.22 Published 2007 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 17403427 Disease Relevance 0 Pain Relevance 0
This study investigates the separate and interactive effects of steroid hormones and thrombin on PAI-1, uPA, and tPA expression by term decidual cells (DCs).
Gene_expression (expression) of PAI-1
20) Confidence 0.22 Published 2007 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 17403427 Disease Relevance 0.28 Pain Relevance 0.14

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