INT159190

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 26.67
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (KRT5) mitochondrion (KRT5) cytoplasm (KRT5)
Anatomy Link Frequency
keratinocytes 3
basal cell 3
Lymph node 1
smooth muscle 1
oocyte 1
KRT5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 19 93.56 High High
abdominal pain 7 82.56 Quite High
Inflammation 122 72.00 Quite High
Chronic pancreatitis 23 66.56 Quite High
epidural 2 62.16 Quite High
Spinal cord 3 59.88 Quite High
cytokine 2 55.88 Quite High
vincristine 1 53.52 Quite High
cINOD 4 50.16 Quite High
backache 1 41.08 Quite Low
Disease Link Frequency Relevance Heat
Cancer 1892 100.00 Very High Very High Very High
Targeted Disruption 361 100.00 Very High Very High Very High
Mesothelioma 290 99.72 Very High Very High Very High
Adenocarcinoma 884 99.64 Very High Very High Very High
Skin Cancer 600 99.64 Very High Very High Very High
Breast Cancer 309 99.58 Very High Very High Very High
Epidermolysis Bullosa Simplex 95 98.92 Very High Very High Very High
Metastasis 334 98.82 Very High Very High Very High
Sarcoma 6 98.80 Very High Very High Very High
Neuroendocrine Cancer 78 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calretinin and CK5/6 were positive, and CEA, S-100 protein, c-kit and CD34 were negative, result in confirmation of a diagnosis of malignant mesothelioma.
Gene_expression (/) of CK5 associated with malignant neoplastic disease and lung cancer
1) Confidence 0.65 Published 2009 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 19346724 Disease Relevance 0.58 Pain Relevance 0.08
In our practice we found use of immunostaining for S100 protein, smooth muscle actin, calponin, cytokeratin 5/6 and cytokeratin 14 to be simple and reliable.
Gene_expression (/) of cytokeratin 5 in smooth muscle
2) Confidence 0.65 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC314417 Disease Relevance 1.03 Pain Relevance 0
The most specific and sensitive markers for mesothelioma are mesothelin (in epithelioid mesothelioma), calretinin and cytokeratin 5/6.
Gene_expression (/) of cytokeratin 5 associated with mesothelioma
3) Confidence 0.65 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2652430 Disease Relevance 1.68 Pain Relevance 0.04
However, according to a recent review article, mesothelin is positive in 27% of squamous cell carcinomas, and calretinin and cytokeratin 5/6 can be raised in both squamous cell carcinoma of the lung and adenocarcinoma of both the lung and other sites [37].
Gene_expression (raised) of cytokeratin 5 in lung associated with adenocarcinoma and skin cancer
4) Confidence 0.65 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2652430 Disease Relevance 1.83 Pain Relevance 0.03
CK5/6, cytokeratin 5/6;
Gene_expression (/) of cytokeratin 5
5) Confidence 0.65 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 0.69 Pain Relevance 0.05
These findings agree with data reported by Stefansson et al. (2005) who verified that CK5/6 expression is more frequent in endometrioid tumors with squamous differentiation [6].
Gene_expression (expression) of CK5 associated with cancer
6) Confidence 0.58 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 0.93 Pain Relevance 0
Otherwise, in the widely well stratified follicular outer root sheath, K5 and K14 are uniformly expressed throughout all layers.
Gene_expression (expressed) of K5
7) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0
In addition to their occurrence in keratinocytes, K5 and K14 are expressed in basal and myoepithelial cells of complex and glandular epithelial tissues (Purkis et al. 1990).
Gene_expression (expressed) of K5 in myoepithelial cells
8) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.17 Pain Relevance 0
Some cells expressed cytokeratin, CK5, desmin and myogenine (Figure 6C).
Gene_expression (expressed) of CK5
9) Confidence 0.40 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.33 Pain Relevance 0.13
Examples of very recent new developments in tumor classification are the recognition of the basal-like subtype of breast cancer on the basis of the expression of K5 and the prognostic relevance of K19 in endocrine pancreatic tumors.
Gene_expression (expression) of K5 associated with cancer, pancreatic cancer and breast cancer
10) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.77 Pain Relevance 0
The expression spectrum of K5 and K14 in tumors corresponds well to the patterns in normal epithelia.
Gene_expression (expression) of K5 associated with cancer
11) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.15 Pain Relevance 0
In contrast to most adenocarcinomas, epithelial mesotheliomas consistently express keratinocyte-type keratins, notably K5, in addition to keratins K8, K18, K19, and K7 typical for simple epithelia (Moll et al. 1989; Ordonez 1998; Chu and Weiss 2002a; Yaziji et al. 2006).
Gene_expression (express) of K5 in keratinocyte associated with adenocarcinoma and mesothelioma
12) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.43 Pain Relevance 0
Lymph node metastasis of a squamous cell carcinoma of the head and neck region, expressing K5 (c; more intensely in the peripheral tumor cell layers) as well as K6 (d; particularly strongly in central tumor cells) as signs of their keratinocyte origin.
Gene_expression (expressing) of K5 in Lymph node associated with cancer, skin cancer and metastasis
13) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
Neuroendocrine tumors, a large and heterogeneous tumor group, are generally characterized by the expression of keratins typical of simple epithelia (notably K8, K18, and—more variably—K19) and the complete lack of keratins K5/K14 typically found in stratified epithelia.
Gene_expression (expression) of K5 associated with neuroendocrine cancer and cancer
14) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.57 Pain Relevance 0
At the moment, the panel of keratins introduced into routine diagnosis as histopathological tumor markers is distinctly small, essentially consisting of K5, K7, K8/K18, K19, and K20.
Gene_expression (consisting) of K5 associated with cancer
15) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.66 Pain Relevance 0
The best performance on paraffin sections is displayed by MAb D5/16B4 (Lobeck et al. 1989; Demirkesen et al. 1995) which—although being often regarded as “K5/K6 antibody”—specifically recognizes K5 (Böcker et al. 2002).
Gene_expression (antibody) of K5
16) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
Furthermore, since keratins also exhibit characteristic expression patterns in human tumors, several of them (notably K5, K7, K8/K18, K19, and K20) have great importance in immunohistochemical tumor diagnosis of carcinomas, in particular of unclear metastases and in precise classification and subtyping.
Gene_expression (expression) of K5 associated with cancer, carcinoma and metastasis
17) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386534 Disease Relevance 0.84 Pain Relevance 0
This involves a switch from expression of the basal cell keratins (K5, K14, K15) to the suprabasal epidermal keratins, the type II keratin K1 and subsequently the type I keratin K10 (Fig. 4b; Fuchs and Green 1980; Moll et al. 1982b; Tseng et al. 1982, Weiss et al. 1984; Roop 1987, Stoler et al. 1988).
Gene_expression (expression) of K5 in basal cell
18) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.62 Pain Relevance 0
Frequently, K5 and K14 can also be detected in the lower suprabasal cell layers (see above and Fig. 4a).
Gene_expression (detected) of K5
19) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.20 Pain Relevance 0.03
Focal K5 expression may be observed in certain adenocarcinoma types, notably in adenocarcinomas of the endometrium, the ovary, and the pancreas, which seems to be related to their potency for focal squamous differentiation (Moll 1998; Chu and Weiss 2002a, 2002b).
Gene_expression (expression) of K5 in pancreas associated with adenocarcinoma and potency
20) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.25 Pain Relevance 0.05

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