INT159232

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.45
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
stroma 1
thyroid 1
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 3 86.72 High High
Dysuria 1 83.56 Quite High
abdominal pain 5 82.40 Quite High
Somatostatin 2 79.92 Quite High
Serotonin 1 76.56 Quite High
positron emission tomography 1 51.76 Quite High
Inflammation 3 38.08 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Merkel Cell Carcinoma 28 98.92 Very High Very High Very High
Metastasis 47 97.88 Very High Very High Very High
Paraganglioma 23 96.40 Very High Very High Very High
Small Cell Lung Cancer 7 96.20 Very High Very High Very High
Neuroendocrine Cancer 16 95.56 Very High Very High Very High
Carcinoid 25 94.84 High High
Cancer 48 92.00 High High
Ganglion Cysts 5 91.92 High High
Carcinoma 2 91.32 High High
Cholestasis 1 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Negative_regulation (positive) of synaptophysin in thyroid
1) Confidence 0.41 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
Immunohistochemistry revealed that this lesion was positive for synaptophysin and CD56, but negative for chromogranin as well as CD10, CD7, and CD20, consistent with a well-differentiated neuroendocrine tumor.
Negative_regulation (positive) of synaptophysin associated with neuroendocrine cancer
2) Confidence 0.41 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2386474 Disease Relevance 1.16 Pain Relevance 0.07
She was also highly positive for chromogranin, synaptophysin and CD117, thus confirming the diagnosis of MCC.
Negative_regulation (positive) of synaptophysin associated with merkel cell carcinoma
3) Confidence 0.41 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2838912 Disease Relevance 1.02 Pain Relevance 0.03
In the described case, the patient was positive for synaptophysin and neuron specific antigen, focally positive for chromogranin, partially positive in stroma for S-100, and negative for cytokeratin.
Spec (partially) Negative_regulation (positive) of synaptophysin in stroma
4) Confidence 0.41 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887868 Disease Relevance 1.66 Pain Relevance 0.20

General Comments

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