INT15941

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Context Info
Confidence 0.58
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 21.07
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
astrocytes 5
plasma 4
blood 2
synovial fluid 1
mandible 1
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 285 100.00 Very High Very High Very High
Angina 35 99.60 Very High Very High Very High
ischemia 55 98.48 Very High Very High Very High
Sciatic nerve 1 98.00 Very High Very High Very High
beta blocker 2 97.42 Very High Very High Very High
anesthesia 20 97.40 Very High Very High Very High
Central nervous system 72 97.28 Very High Very High Very High
Neuropathic pain 1 97.08 Very High Very High Very High
Inflammatory marker 17 95.52 Very High Very High Very High
fibrosis 74 92.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 335 100.00 Very High Very High Very High
Coronary Artery Disease 29 99.92 Very High Very High Very High
Cv General 3 Under Development 35 99.60 Very High Very High Very High
Cancer 334 99.48 Very High Very High Very High
Hypertension 75 99.40 Very High Very High Very High
Targeted Disruption 94 99.38 Very High Very High Very High
Increased Venous Pressure Under Development 90 99.32 Very High Very High Very High
Coagulation Disorder 13 99.18 Very High Very High Very High
Breast Cancer 92 99.12 Very High Very High Very High
Recurrence 2 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig. 5b shows that MSC treatment significantly increased the tPA mRNA level and concomitantly decreased the PAI-1 mRNA level.
Negative_regulation (decreased) of PAI
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.66 Pain Relevance 0
Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI-1 activity.
Negative_regulation (decreased) of PAI-1 associated with coagulation disorder
2) Confidence 0.55 Published 2003 Journal Masui Section Abstract Doc Link 12632627 Disease Relevance 0.18 Pain Relevance 0.09
uPA levels in postmenopausal women increase, while PAI-1 and PGE2 decrease, after treatment with high dose celecoxib
Negative_regulation (decrease) of PAI-1
3) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
[Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency].
Negative_regulation (deficiency) of activator inhibitor-1
4) Confidence 0.48 Published 2003 Journal Masui Section Title Doc Link 12632627 Disease Relevance 0.18 Pain Relevance 0.09
The genetic deficiency of PAI-1 in mice is associated to impaired blood vascularisation in several experimental models [9], [12], [18] such as cancer [10], [13] and choroidal angiogenesis models [11], [14].
Negative_regulation (deficiency) of PAI-1 in blood associated with cancer
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.29 Pain Relevance 0.03
Surprisingly, we previously reported that neither PAI-1 deficiency nor a pharmacological inhibitor of serine proteases directly affect the endothelial cell sprouting from thoracic duct explants in the lymphatic ring assay [29].
Neg (neither) Negative_regulation (deficiency) of PAI-1 in thoracic duct
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.38 Pain Relevance 0.07
PAI-1 deficiency did neither affect the development of lymphangioma nor burn-induced corneal lymphangiogenesis.
Negative_regulation (deficiency) of PAI-1 associated with burns and lymphangioma
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2836381 Disease Relevance 0.88 Pain Relevance 0.10
To address this issue, we studied the impact of PAI-1 deficiency in various murine models of tumoral lymphangiogenesis.
Negative_regulation (deficiency) of PAI-1
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2836381 Disease Relevance 0.60 Pain Relevance 0.06
Using LCM, we have demonstrated that astrocytes in the IBZ respond to MSC treatment by increasing tPA activity (i.e. increase of tPA level with a concomitant decrease of PAI-1 level).
Negative_regulation (decrease) of PAI in astrocytes
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.38 Pain Relevance 0
Gene array analysis of primary astrocyte cultures derived from wild-type (WT) and glial fibrillary acidic protein (GFAP)/vimentin (Vim) double knock-out mice reveal that only the PAI-1 gene, out of 1200 genes measured was downregulated by threefold or higher in the knock-out animals [22].
Negative_regulation (downregulated) of PAI in astrocyte associated with targeted disruption
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.56 Pain Relevance 0.21
In vivo, administration of MSCs to mice subjected to middle cerebral artery occlusion (MCAo) significantly increased activation of tPA and downregulated PAI-1 levels in the ischemic boundary zone (IBZ) compared with control PBS treated mice, concurrently with increases of myelinated axons and synaptophysin.
Negative_regulation (downregulated) of PAI in MSCs associated with middle cerebral artery infarction
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815778 Disease Relevance 0.37 Pain Relevance 0.09
MSC co-culture significantly increased tPA and decreased the PAI-1 protein levels in normal and OGD astrocytes compared to normal and OGD astrocytes without MSC co-culture, respectively (1d).


Negative_regulation (decreased) of PAI in astrocytes
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.12 Pain Relevance 0
As a member of the serpine gene family, PAI-1 is the major inhibitor of tPA [21], and is largely produced by reactive astrocytes in the CNS after stroke [65], [66].
Negative_regulation (inhibitor) of PAI in astrocytes associated with stroke and central nervous system
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.42 Pain Relevance 0.09
These data indicate that astrocytes in the IBZ respond to MSC treatment and increase tPA and concomitantly decrease PAI-1 gene expression.


Negative_regulation (decrease) of PAI in astrocytes
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.62 Pain Relevance 0
Therefore, we hypothesize that MSCs decrease PAI-1 expression and stimulate tPA after ischemia and thereby promote neurite remodeling.
Negative_regulation (decrease) of PAI in neurite associated with ischemia
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.66 Pain Relevance 0.22
A 21-year-old male with congenital PAI-1 deficiency underwent wisdom teeth extraction of the mandible under general anesthesia using propofol, nitrous oxide, sevoflurane, fentanyl, and vecuronium.
Negative_regulation (deficiency) of PAI-1 in mandible associated with anesthesia
16) Confidence 0.40 Published 2003 Journal Masui Section Abstract Doc Link 12632627 Disease Relevance 0.18 Pain Relevance 0.10
Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI-1 activity.
Negative_regulation (deficiency) of PAI-1 associated with coagulation disorder
17) Confidence 0.40 Published 2003 Journal Masui Section Abstract Doc Link 12632627 Disease Relevance 0.17 Pain Relevance 0.08
PAI-1 and p-Smad2 determined from Western blotting, among treated groups, was decreased compared to CONT group.
Negative_regulation (decreased) of PAI-1
18) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2799997 Disease Relevance 0.65 Pain Relevance 0.39
This variant is associated with elevated PAI-1 protein levels, impaired fibrinolysis, and increased risk of thrombosis.
Negative_regulation (impaired) of PAI-1 associated with thrombosis
19) Confidence 0.37 Published 2006 Journal Arch Dermatol Section Abstract Doc Link 17116837 Disease Relevance 0.58 Pain Relevance 0.07
PAI-1 is the most important physiological inhibitor of tissue plasminogen activator and, therefore, exerts pro-thrombotic effects.
Negative_regulation (inhibitor) of PAI
20) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.12 Pain Relevance 0

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