INT159442

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Context Info
Confidence 0.70
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.86
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm8) transmembrane transport (Trpm8)
Anatomy Link Frequency
sensory neurons 2
neurons 2
Trpm8 (Mus musculus)
Pain Link Frequency Relevance Heat
allodynia 119 99.90 Very High Very High Very High
Neuropathic pain 100 99.70 Very High Very High Very High
qutenza 14 99.70 Very High Very High Very High
imagery 33 98.60 Very High Very High Very High
agonist 30 98.52 Very High Very High Very High
peripheral neuropathy 7 96.20 Very High Very High Very High
Pain 99 95.48 Very High Very High Very High
TRP channel 23 95.08 Very High Very High Very High
Eae 44 88.56 High High
Sciatic nerve 18 85.76 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 245 99.90 Very High Very High Very High
Hypersensitivity 34 99.30 Very High Very High Very High
Injury 201 97.00 Very High Very High Very High
Peripheral Neuropathy 4 96.20 Very High Very High Very High
Nervous System Injury 78 95.84 Very High Very High Very High
Pain 93 95.48 Very High Very High Very High
Nociception 57 94.36 High High
Targeted Disruption 21 94.08 High High
Hyperalgesia 47 84.68 Quite High
Ganglion Cysts 53 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An injection of oxaliplatin increased the expression level of TRPM8 mRNA at day 3 after injection and the expression was decreased to the near-normal level on days 10 and 25.
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 mRNA
1) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.47 Pain Relevance 0.53
These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents.
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 associated with allodynia
2) Confidence 0.70 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.52 Pain Relevance 0.50
This suggests that cold hypersensitivity in neuropathic pain is not always dependent upon increased expression of TRPA1 and TRPM8 in DRG.


Neg (not) Positive_regulation (dependent) of Gene_expression (expression) of TRPM8 associated with hypersensitivity and neuropathic pain
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.68 Pain Relevance 0.29
Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice.
Positive_regulation (increased) of Gene_expression (expression) of transient receptor potential melastatin 8 associated with qutenza and allodynia
4) Confidence 0.61 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19375484 Disease Relevance 0.49 Pain Relevance 0.64
In contrast to our finding, a recent report showed that mice with oxaliplatin-induced cold allodynia had increased TRPM8 mRNA expression [56].
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 mRNA associated with allodynia
5) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.34 Pain Relevance 0.28
These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents.
Positive_regulation (increased) of Gene_expression (expression) of TRPM8 associated with allodynia
6) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19375484 Disease Relevance 0.52 Pain Relevance 0.50
Prior to experiment, HEK293 cells transfected with the TRPM8-wt/Y745H constructs were incubated with 5 ?
Positive_regulation (transfected) of Gene_expression (transfected) of TRPM8
7) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.06 Pain Relevance 0.18
However, we find no evidence of increased expression of TRPM8 and TRPA1, or of changes in the cold sensitivity of sensory neurons after injury.


Positive_regulation (increased) of Gene_expression (expression) of TRPM8 in sensory neurons associated with injury
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.15 Pain Relevance 0.90
This suggests that cold hypersensitivity in neuropathic pain is not always dependent upon increased expression of TRPA1 and TRPM8 in DRG.


Positive_regulation (increased) of Gene_expression (expression) of TRPM8 associated with hypersensitivity and neuropathic pain
9) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.68 Pain Relevance 0.28
This specificity difference is reflected by the fact that TRPM8+ neurons are unaffected in Wood's ablation experiment [39], whereas TRPM8 expression was absent in Runx1 L-CKO mice using Kuner's Nav1.8Cre line (Fig. 1B).
Positive_regulation (absent) of Neg (absent) Gene_expression (expression) of TRPM8 in neurons
10) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.96 Pain Relevance 1.24

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