INT159476

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.43
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (NOS3) aging (NOS3) Golgi apparatus (NOS3)
mitochondrion organization (NOS3) cytoplasm (NOS3) cytosol (NOS3)
Anatomy Link Frequency
endothelial cells 2
platelets 2
NOS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 420 92.96 High High
Inflammation 29 61.84 Quite High
cytokine 13 60.80 Quite High
aspirin 4 50.00 Quite Low
bradykinin 8 19.92 Low Low
b2 receptor 5 8.08 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 27 92.64 High High
Metabolic Syndrome 15 90.44 High High
Hypertension 20 89.96 High High
Diabetes Mellitus 83 89.40 High High
Increased Venous Pressure Under Development 34 78.04 Quite High
Apoptosis 94 73.36 Quite High
Stress 41 66.92 Quite High
INFLAMMATION 30 61.84 Quite High
Hyperlipidemia 4 60.12 Quite High
Adhesions 21 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine phosphorylation of NOS-3 in platelets was decreased, and this was especially marked for serine-1177 phosphorylation, whereas acetylation of NOS-3 was increased, by aspirin incubation.
Positive_regulation (increased) of Phosphorylation (acetylation) of NOS-3 in platelets
1) Confidence 0.44 Published 2009 Journal Cardiovasc. Res. Section Body Doc Link 19377066 Disease Relevance 0 Pain Relevance 0
-regulated PKC activation and phosphorylation of Ser145 and Thr337 and another involving eNOS phosphorylation and activation leading the NO/cGMP-regulated PKG phosphorylation of Ser331.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of eNOS
2) Confidence 0.20 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
Normally, stimulation of NO production by insulin is mediated by signaling pathways involving activation of Phosphoinositide-3 (PI-3) kinase leading to phosphorylation of eNOS.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of eNOS
3) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.20 Pain Relevance 0.06
This, in turn, triggers the rapid and dynamic activation of Ca2+/calmodulin-sensitive NO synthases (NOS), such as through Ser1177 phosphorylation and activation of eNOS, promoting the synthesis of NO from l-Arg.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of eNOS
4) Confidence 0.17 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.13
Whilst our data have indeed confirmed that both thrombin and U46619 can readily lead to eNOS phosphorylation at Ser1177 in HEK 293 cells, we have not explored whether that eNOS activation occurs through PKC?
Spec (whether) Positive_regulation (through) of Phosphorylation (phosphorylation) of eNOS
5) Confidence 0.17 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.05 Pain Relevance 0.05
This, in turn, triggers the rapid and dynamic activation of Ca2+/calmodulin-sensitive NO synthases (NOS), such as through Ser1177 phosphorylation and activation of eNOS, promoting the synthesis of NO from l-Arg.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of eNOS
6) Confidence 0.17 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.14
Furthermore, as stated, through further recent studies it has been demonstrated that thrombin can directly lead to eNOS phosphorylation at Ser1177/1179 in bovine aortic endothelial cells in a mechanism involving Gq/PLC?
Positive_regulation (lead) of Phosphorylation (phosphorylation) of eNOS in endothelial cells
7) Confidence 0.16 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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