INT159775

From wiki-pain
Revision as of 23:42, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.36
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
blood vessels 3
stem cells 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 35 100.00 Very High Very High Very High
fibrosis 72 96.16 Very High Very High Very High
cytokine 37 92.20 High High
potassium channel 1 91.44 High High
antagonist 2 89.52 High High
Inflammatory marker 1 87.04 High High
ischemia 42 84.08 Quite High
Inflammation 60 82.72 Quite High
anesthesia 5 76.68 Quite High
chemokine 5 68.36 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 4 100.00 Very High Very High Very High
Infarction 124 99.84 Very High Very High Very High
Ganglion Cysts 3 99.48 Very High Very High Very High
Fibrosis 69 98.04 Very High Very High Very High
Epiretinal Membrane 1 97.52 Very High Very High Very High
Diabetes Mellitus 61 95.84 Very High Very High Very High
Myocardial Infarction 203 94.96 High High
Nephrotoxicity 3 92.08 High High
Cirrhosis 46 91.04 High High
Apoptosis 52 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While gene expression of Abcc9, Bard1 and Casp4 has increased significantly in the Post group, compared to Ischemic group, gene expression of Lyz, Timp1 and Casp8 has reduced significantly.
Negative_regulation (reduced) of Gene_expression (expression) of Timp1
1) Confidence 0.37 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872860 Disease Relevance 0.59 Pain Relevance 0.31
TIMP-1 (tissue inhibitor of metallopeptidase1) expression is regulated through STAT3 [38] and TIMP-1 is induced in the epiretinal membranes of Type 1 and Type 2 diabetic patients [39].
Negative_regulation (inhibitor) of Gene_expression (expression) of TIMP-1 associated with epiretinal membrane and diabetes mellitus
2) Confidence 0.34 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 1.13 Pain Relevance 0.23
In our study, we observed that expression of Tissue inhibitors of metalloproteinases (TIMP1, 2) decreased in infarction area of myocardium in the AdV-SDF-1 group, which was concordance with much more stem cells and blood vessels.
Negative_regulation (decreased) of Gene_expression (expression) of TIMP1 in blood vessels associated with metalloproteinase and infarction
3) Confidence 0.25 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.18 Pain Relevance 0.08
Interestingly, TIMP-1 overexpression in pancreatic cancer cells reduced angiogenesis and cell implantation, this anti-angiogenic activity of TIMP-1 involved in part MMP-inhibition [33].
Negative_regulation (reduced) of Gene_expression (overexpression) of TIMP-1 associated with pancreatic cancer
4) Confidence 0.25 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.16 Pain Relevance 0.07
1 down-regulation caused by SDF-1 was associated with decreased collagen accumulation and down-regulated TIMP-1 expression in the infarction area.
Negative_regulation (down-regulated) of Gene_expression (expression) of TIMP-1 associated with infarction
5) Confidence 0.25 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.64 Pain Relevance 0.08
PFD caused a decrease in collagen III and TIMP-1 mRNA expression, suggesting that it could attenuate the limited fibrotic potential of tacrolimus [62].
Negative_regulation (decrease) of Gene_expression (expression) of TIMP-1 mRNA associated with fibrosis
6) Confidence 0.12 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.81 Pain Relevance 0.16
We found that treatment of the cells with NIM811 increased collagenase activity, accompanied by stimulation of the transcription and synthesis of MMP-1 and weak suppression of the expression of TIMP-1 (Figs 2 and 3).
Negative_regulation (suppression) of Gene_expression (expression) of TIMP-1
7) Confidence 0.10 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.60 Pain Relevance 0.06
In our study, we observed that expression of Tissue inhibitors of metalloproteinases (TIMP1, 2) decreased in infarction area of myocardium in the AdV-SDF-1 group, which was concordance with much more stem cells and blood vessels.
Negative_regulation (decreased) of in stem cells Gene_expression (expression) of TIMP1 in blood vessels associated with metalloproteinase and infarction
8) Confidence 0.08 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.18 Pain Relevance 0.08
CONCLUSION: AMI patients treated with PCI had an early significant reduction in MMP-9, MMP-9/TIMP-1 ratio and PAPP-A when compared to patients with stable angina pectoris treated with PCI.
Negative_regulation (reduction) of Gene_expression (ratio) of TIMP-1
9) Confidence 0.04 Published 2009 Journal Thromb. Res. Section Body Doc Link 19410278 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox