INT159853

Context Info Confidence 0.17 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0.07

extracellular space (IL2) extracellular region (IL2) Golgi apparatus (RHO) cell adhesion (IL2) plasma membrane (RHO) signal transducer activity (RHO)

Anatomy Link Frequency T cells 3 IL2 (Homo sapiens) RHO (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 66.12

Disease Link Frequency Relevance Heat Stress 1 92.84 INFLAMMATION 1 65.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, we demonstrated that pomalidomide was able to regulate the activity of Rho GTPases and the formation of F-actin in primary human T cells as it did in monocytes and showed that the activation of RhoA was essential for pomalidomide-induced interleukin-2 expression in T cells.

Gene_expression (expression) of interleukin-2 in T cells Regulation (regulate) of Gene_expression (activity) of Rho in T cells

1) Confidence 0.17 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.16 Pain Relevance 0.07

General Comments

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