INT1599

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Context Info
Confidence 0.67
First Reported 1973
Last Reported 2011
Negated 6
Speculated 1
Reported most in Abstract
Documents 146
Total Number 147
Disease Relevance 30.05
Pain Relevance 64.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
embryonic kidney 4
ovary 4
SK-N-SH 2
nucleus accumbens 2
atrium 2
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 261 100.00 Very High Very High Very High
Opioid 139 100.00 Very High Very High Very High
nMDA receptor 34 100.00 Very High Very High Very High
MU agonist 27 100.00 Very High Very High Very High
Nucleus accumbens 26 100.00 Very High Very High Very High
opioid receptor 152 99.96 Very High Very High Very High
Kappa opioid receptor 28 99.96 Very High Very High Very High
antagonist 308 99.92 Very High Very High Very High
Kinase C 41 99.92 Very High Very High Very High
tolerance 36 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 87 99.96 Very High Very High Very High
Headache 30 99.48 Very High Very High Very High
Neuroblastoma 44 99.38 Very High Very High Very High
Opiate Addiction 10 99.32 Very High Very High Very High
Hypersensitivity 57 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 97 99.10 Very High Very High Very High
Obesity 46 99.10 Very High Very High Very High
INFLAMMATION 335 98.88 Very High Very High Very High
Ganglion Cysts 101 98.42 Very High Very High Very High
Anaphylaxis 106 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contractility of the crucian carp atrium seems to be tuned high by tonic activation of the adenylate cyclase-cAMP pathway, arguably to increase the scope of cholinergic regulation through the accentuated antagonism of adrenergic and cholinergic mechanisms [17].
Positive_regulation (activation) of adenylate cyclase in atrium
1) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.23 Pain Relevance 0.17
Phosphorylation of L-type Ca2+ channels due to tonic activation of adenylate cyclase is not uncommon for the vertebrate atrial tissue and may hold true also for the crucian carp atrium.
Positive_regulation (activation) of adenylate cyclase in atrium
2) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.05 Pain Relevance 0.06
In the present study, concentrations of Ca2+ that stimulate brain adenylylcyclase inhibit the adenylylcyclase of NCB-20 plasma membranes.
Positive_regulation (stimulate) of adenylylcyclase in plasma
3) Confidence 0.67 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 1848232 Disease Relevance 0 Pain Relevance 0.13
DPDPE-induced adenylyl cyclase supersensitization was not associated with an increase in the phosphorylation of CREBs.
Positive_regulation (induced) of adenylyl cyclase
4) Confidence 0.59 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.11 Pain Relevance 0.75
Most, though not all, of the effects of catecholamines at beta-receptors are mediated through activation of adenyl cyclase and increases in cyclic AMP accumulation.
Positive_regulation (activation) of adenyl cyclase associated with catecholamine
5) Confidence 0.57 Published 1984 Journal Drugs Section Abstract Doc Link 6098436 Disease Relevance 0.09 Pain Relevance 0.41
These results indicate that subtypes adenylyl cyclase I, III and VIII, which are activated by calcium, and adenylyl cyclase V and VI, which are inhibited by calcium, are not dominant isoforms in granulosa-lutein cells.
Positive_regulation (activated) of cyclase in lutein cells
6) Confidence 0.55 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.24
Adenylyl cyclase (AC) superactivation, induced by chronic opioid agonist administration, is regarded as one of the molecular mechanisms leading to tolerance.
Positive_regulation (induced) of Adenylyl cyclase associated with mu agonist and tolerance
7) Confidence 0.51 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16750187 Disease Relevance 0.10 Pain Relevance 0.79
These findings suggest that buprenorphine was binding (pseudo)irreversibly to the opiate receptor, resulting in a persistent inhibition of cAMP synthesis which masks the etorphine-induced enhancement of adenylyl cyclase activity.
Positive_regulation (enhancement) of cyclase associated with opiate, immobilon and buprenorphine
8) Confidence 0.50 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8380866 Disease Relevance 0.20 Pain Relevance 1.54
In clarifying the possible involvement of cyclic AMP (cAMP) in prostaglandin (PG) E2-induced sensitization of the bradykinin response of canine testicular polymodal receptors, the effects of forskolin, an activator of adenylyl cyclase, were studied in the presence and absence of acetylsalicylic acid (ASA, 550 microM) which blocks PG production.
Positive_regulation (activator) of adenylyl cyclase associated with aspirin and bradykinin
9) Confidence 0.48 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8177499 Disease Relevance 0 Pain Relevance 0.24
These studies showed that G(z) could mediate acute actions of mu- and kappa-opioids but G(z) alone was insufficient to mediate adenylyl cyclase supersensitization induced by the chronic activation of opioid receptors.
Positive_regulation (induced) of adenylyl cyclase associated with opioid receptor and opioid
10) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.15 Pain Relevance 0.82
These studies showed that G(z) could mediate acute actions of mu- and kappa-opioids but G(z) alone was insufficient to mediate adenylyl cyclase supersensitization induced by the chronic activation of opioid receptors.
Positive_regulation (mediate) of adenylyl cyclase associated with opioid receptor and opioid
11) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.15 Pain Relevance 0.87
However, adenylyl cyclase supersensitization induced by chronic opioid treatments remained sensitive to pertussis toxin.
Positive_regulation (induced) of adenylyl cyclase associated with bordatella infection and opioid
12) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.27 Pain Relevance 0.92
G(z) can mediate the acute actions of mu- and kappa-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization.
Positive_regulation (opioid-induced) of adenylyl cyclase associated with opioid
13) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10991975 Disease Relevance 0.23 Pain Relevance 0.76
Our previous study showed that opioid-induced adenylyl cyclase supersensitization in human embryonic kidney (HEK) 293 cells expressing the delta-opioid receptor requires G(i) but not G(z) proteins.
Positive_regulation (opioid-induced) of adenylyl cyclase in HEK associated with opioid receptor and opioid
14) Confidence 0.48 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991975 Disease Relevance 0.22 Pain Relevance 0.65
Many different types of cells develop increased adenylyl cyclase activity (sensitization) on prior treatment with drugs such as opiates that acutely inhibit the enzyme.
Positive_regulation (increased) of cyclase associated with opiate
15) Confidence 0.47 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8622641 Disease Relevance 0 Pain Relevance 0.17
Ligand binding assays ([(3)H]5-CT), membrane localization and functional studies in transiently transfected cells indicated that all three splice variants are well expressed on the membrane and no major differences in their respective pharmacology and their ability to activate adenylyl cyclase were observed.
Positive_regulation (activate) of adenylyl cyclase
16) Confidence 0.46 Published 2008 Journal Gene Section Abstract Doc Link 18793707 Disease Relevance 0.47 Pain Relevance 0.26
Arginine vasopressin (AVP) is a potent activator of renal adenyl cyclase [25].
Positive_regulation (activator) of adenyl cyclase
17) Confidence 0.45 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.10 Pain Relevance 0.11
A reduced capability to inhibit forskolin-stimulated adenylyl cyclase activity in headache patients was observed.
Positive_regulation (forskolin-stimulated) of adenylyl cyclase associated with headache
18) Confidence 0.45 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11298662 Disease Relevance 0.90 Pain Relevance 0.99
Carbachol (100 microM) did not stimulate adenylyl cyclase activity.
Neg (not) Positive_regulation (stimulate) of adenylyl cyclase
19) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.14 Pain Relevance 0.22
VIP (10 microM), prostaglandin E1 (30 microM) and forskolin (10 microM) all increased adenylyl cyclase activity 8- to 10-fold above the activity with 1 microM GTP.
Positive_regulation (increased) of adenylyl cyclase
20) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1347631 Disease Relevance 0.15 Pain Relevance 0.21

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