INT16003

Context Info Confidence 0.65 First Reported 1991 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 7 Disease Relevance 4.68 Pain Relevance 0.77

peptidase activity (Phex) Golgi apparatus (Phex) endoplasmic reticulum (Phex)

Anatomy Link Frequency osteoblasts 3 osteocyte 2 Hyp3 1 Neutrophil 1 Phex (Mus musculus)

Pain Link Frequency Relevance Heat Opioid 3 99.08 Enkephalin 5 97.20 Neurotransmitter 1 94.08 Antinociceptive 2 93.92 Neuropeptide 1 84.92 Pain 5 32.00 narcan 1 25.00 nociceptor 1 25.00 Somatostatin 5 5.00

Disease Link Frequency Relevance Heat Rickets 365 100.00 Hypercalcemia 15 95.12 Hypophosphatemia 55 89.20 Cancer 60 80.88 Paraneoplastic Syndromes 5 77.12 Disease 50 76.08 Ossifying Fibroma 5 66.72 Familial Hypophosphatemia 15 66.36 Growth Problems 5 63.20 Congenital Anomalies 15 42.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.

Gene_expression (expressed) of PHEX in osteoblasts

1) Confidence 0.65 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0

The encoded endopeptidase (PHEX) is membrane-bound and expressed mainly by osteoblasts in bone and odontoblasts in teeth, with no expression in the kidney [18].

Neg (no) Gene_expression (expressed) of PHEX in osteoblasts

2) Confidence 0.58 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.96 Pain Relevance 0

It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.

Gene_expression (expressed) of PHEX in osteocyte associated with rickets

3) Confidence 0.58 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.42 Pain Relevance 0

As with PHEX and FGF23, DMP1 is highly expressed in cells of the osteoblasts/osteocyte lineage.

Gene_expression (expressed) of PHEX in osteocyte

4) Confidence 0.22 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 1.44 Pain Relevance 0

It is of interest that the mRNA of all three factors (FGF23, PHEX and DMP1) involved in the pathogenesis of hypophosphataemic rickets are highly expressed in cells of the osteoblasts/osteocyte lineage.

Gene_expression (expressed) of PHEX in osteoblasts associated with rickets

5) Confidence 0.20 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.42 Pain Relevance 0

[Hyp3]-tuftsin (Thr-Lys-Hyp-Arg) has been synthesized by the liquid-phase method.

Gene_expression (synthesized) of Thr-Lys-Hyp-Arg in Hyp3

6) Confidence 0.04 Published 1991 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1783492 Disease Relevance 0 Pain Relevance 0.09

Neutrophil neutral endopeptidase variation and its regulation by opioid peptides.

Gene_expression (variation) of Neutrophil neutral endopeptidase in Neutrophil associated with opioid

7) Confidence 0.01 Published 2001 Journal Int. Immunopharmacol. Section Title Doc Link 11367540 Disease Relevance 0 Pain Relevance 0.68

General Comments

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