INT160256

Context Info Confidence 0.30 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 3.16 Pain Relevance 0.34

signal transduction (F2rl2) plasma membrane (F2rl2) signal transducer activity (F2rl2)

F2rl2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 23 97.60 cytokine 10 93.24 Inflammation 7 90.56 cva 1 81.36 ischemia 2 76.44 Mechanotransduction 4 65.08 Inflammatory mediators 3 60.48 addiction 2 28.44 antagonist 2 28.16 Antinociceptive 1 25.00

Disease Link Frequency Relevance Heat Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 12 99.74 Increased Venous Pressure Under Development 63 99.38 Diarrhoea 1 99.32 Injury 56 98.76 Atherosclerosis 1 97.68 Stress 40 92.56 Inflammatory Bowel Disease 11 90.72 Hypertrophy 3 90.64 INFLAMMATION 11 90.56 Penetrating Head Injuries 5 86.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated colonic hypersensitivity in mice.

Gene_expression (evokes) of proteinase-activated receptor associated with diarrhoea

1) Confidence 0.30 Published 2009 Journal Pain Section Abstract Doc Link 19450926 Disease Relevance 0.47 Pain Relevance 0

At least as attractive, and not mutually exclusive is the hypothesis that arterial injury, like in early atherosclerosis, will up-regulate endothelial expression of proteinase-activated-receptor 2 [53], which will be activated proteolytically within the atherosclerotic lesion and via systemic proteases to specifically sensitize endothelial TRPV4 channels to respond to mechanical stress [34].

Gene_expression (expression) of proteinase-activated-receptor 2 associated with stress, atherosclerosis, injury and increased venous pressure under development

2) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1959246 Disease Relevance 1.20 Pain Relevance 0.16

The induced levels of the protease-activated receptor, PAR-1, were significantly attenuated in IL-1R1-null mice.

Gene_expression (levels) of protease-activated receptor

3) Confidence 0.21 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.89 Pain Relevance 0.17

General Comments

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